PDB entry 1kmc

View 1kmc on RCSB PDB site
Description: Crystal Structure of the Caspase-7 / XIAP-BIR2 Complex
Class: apoptosis/hydrolase
Keywords: complex, iap, caspase, apoptosis, bir, apoptosis/hydrolase complex
Deposited on 2001-12-14, released 2002-01-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.234
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: caspase-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55210 (Start-302)
      • engineered (185)
    Domains in SCOPe 2.06: d1kmca_
  • Chain 'B':
    Compound: caspase-7
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55210
      • engineered (185)
    Domains in SCOPe 2.06: d1kmcb_
  • Chain 'C':
    Compound: x-linked inhibitor of apoptosis protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1kmcc_
  • Chain 'D':
    Compound: x-linked inhibitor of apoptosis protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1kmcd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1kmcA (A:)
maddqgcieeqgvedsanedsvdakpdrssfvpslfskkkknvtmrsikttrdrvptyqy
nmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcscakmq
dllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktllekpkl
ffiqaargtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrspgrgsw
fvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkely
fsq

    Sequence, based on observed residues (ATOM records): (download) 
    >1kmcA (A:)
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktlle
kpklffiqaargtelddgiqrykipveadflfaystvpgyyswrspgrgswfvqalcsil
eehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfsq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1kmcB (B:)
maddqgcieeqgvedsanedsvdakpdrssfvpslfskkkknvtmrsikttrdrvptyqy
nmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcscakmq
dllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktllekpkl
ffiqaargtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrspgrgsw
fvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkely
fsq

    Sequence, based on observed residues (ATOM records): (download) 
    >1kmcB (B:)
ptyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcs
cakmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktll
ekpklffiqaargtelddgiqrykipveadflfaystvpgyyswrspgrgswfvqalcsi
leehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1kmcC (C:)
rdhfaldrpsethadyllrtgqvvdisdtiyprnpamyceearlksfqnwpdyahltpre
lasaglyytgigdqvqcfccggklknwepcdrawsehrrhfpncffvlgrnlnirsesd

    Sequence, based on observed residues (ATOM records): (download) 
    >1kmcC (C:)
ethadyllrtgqvvdis

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1kmcD (D:)
rdhfaldrpsethadyllrtgqvvdisdtiyprnpamyceearlksfqnwpdyahltpre
lasaglyytgigdqvqcfccggklknwepcdrawsehrrhfpncffvlgrnlnirsesd

    Sequence, based on observed residues (ATOM records): (download) 
    >1kmcD (D:)
ethadyllrtgqvvdis