PDB entry 1klk

View 1klk on RCSB PDB site
Description: crystal structure of pneumocystis carinii dihydrofolate reductase ternary complex with pt653 and nadph
Class: oxidoreductase
Keywords: Structure-based design, antifolate, AIDS, protein-inhibitor complex
Deposited on 2001-12-12, released 2002-12-12
The last revision prior to the SCOP 1.75 freeze date was dated 2002-12-12, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.196
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Rattus norvegicus
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1klka_
  • Heterogens: PMD, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1klkA (A:)
mnqqksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrk
twesiplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinri
fviggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdlesw
vgtkvphgkinedgfdyefemwtrdl

    Sequence, based on observed residues (ATOM records): (download) 
    >1klkA (A:)
qksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrktwe
siplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinrifvi
ggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdleswvgt
kvphgkinedgfdyefemwtrdl