PDB entry 1kf9

View 1kf9 on RCSB PDB site
Description: phage display derived variant of human growth hormone complexed with two copies of the extracellular domain of its receptor
Class: hormone/growth factor
Keywords: cytokine, hormone-receptor complex, phage display molecular plasticity, receptor homodimerization, human growth hormone, hormone/growth factor complex
Deposited on 2001-11-19, released 2002-11-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.234
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phage display derived variant human growth hormone
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1KF9
    Domains in SCOPe 2.08: d1kf9a_
  • Chain 'B':
    Compound: extracellular domain human growth hormone receptor (1-238)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kf9b1, d1kf9b2
  • Chain 'C':
    Compound: extracellular domain human growth hormone receptor (1-238)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kf9c1, d1kf9c2
  • Chain 'D':
    Compound: phage display derived variant human growth hormone
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1KF9 (0-End)
    Domains in SCOPe 2.08: d1kf9d_
  • Chain 'E':
    Compound: extracellular domain human growth hormone receptor (1-238)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kf9e1, d1kf9e2
  • Chain 'F':
    Compound: extracellular domain human growth hormone receptor (1-238)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kf9f1, d1kf9f2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1kf9A (A:)
    fptiplsrladnawlradrlnqlafdtyqefeeayipkeqihsfwwnpqtslcpsesipt
    psnkeetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
    iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfnkdmskvstylrtv
    qcrsvegscgf
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9A (A:)
    fptiplsrladnawlradrlnqlafdtyqefeeayipkeqihsfwwnpqtslcpsesipt
    psnkeetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
    iqtlmgrlllknygllycfnkdmskvstylrtvqcrsscg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1kf9B (B:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqmsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9B (B:)
    pkftkcrsperetfschwtpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsi
    wipycikltsnggtvdekcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprna
    diqkgwmvleyelqykevnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnyg
    efsevlyvtlpqm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1kf9C (C:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqmsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9C (C:)
    pkftkcrsperetfschwtiqlfytrrnewkecpdyvsagenscyfnssftsiwipycik
    lkcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyk
    evnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlp
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1kf9D (D:)
    fptiplsrladnawlradrlnqlafdtyqefeeayipkeqihsfwwnpqtslcpsesipt
    psnkeetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
    iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfnkdmskvstylrtv
    qcrsvegscgf
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9D (D:)
    fptiplsrladnawlradrlnqlafdtyqefeeayipkeqihsfwwtslcpsesiptpsn
    keetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleegiqt
    lmgrlllknygllycfnkdmskvstylrtvqcrsvscg
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1kf9E (E:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqmsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9E (E:)
    pkftkcrsperetfschwtlgpiqlfytrrntqewtqewkecpdyvsagenscyfnssft
    siwipycikltsnggtvdekcfsvdeivqpdppialnwtllnvsltgihadiqvrweapr
    nadiqkgwmvleyelqykevnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgn
    ygefsevlyvtlp
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1kf9F (F:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqmsq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1kf9F (F:)
    pkftkcrsperetfschwtiqlfytrrqewkecpdyvsagenscyfnssftsiwipycik
    ltsnggtvdekcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwm
    vleyelqykevnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevly
    vtlp