PDB entry 1k74
View 1k74 on RCSB PDB site
Description: The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Class: transcription
Keywords: The heterodimer of the nuclear receptor ligand binding domains of RXRalpha and PPARgamma bound respectively with 9-cis retinoic acid and GW409544 and coactivator peptides, TRANSCRIPTION
Deposited on
2001-10-18, released
2001-12-05
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-12-26, with a file datestamp of
2012-12-21.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.238
AEROSPACI score: 0.32
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Retinoic acid receptor RXR-alpha
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1k74a_ - Chain 'B':
Compound: steroid receptor coactivator
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Peroxisome proliferator activated receptor gamma
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1k74d_ - Chain 'E':
Compound: steroid receptor coactivator
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: 9CR, 544, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1k74A (A:)
sanedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewak
riphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvga
ifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayc
khkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqmt
Sequence, based on observed residues (ATOM records): (download)
>1k74A (A:)
nedmpverileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewakri
phfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaif
drvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckh
kypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleap
- Chain 'B':
No sequence available.
- Chain 'D':
Sequence, based on SEQRES records: (download)
>1k74D (D:)
mkkghhhhhhgpesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmns
lmmgedkikfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndq
vtllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkf
nalelddsdlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfak
llqkmtdlrqivtehvqllqvikktetdmslhpllqeiykdly
Sequence, based on observed residues (ATOM records): (download)
>1k74D (D:)
pesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfk
hitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvhei
iytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdla
ifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqi
vtehvqllqvikktetdmslhpllqeiykdly
- Chain 'E':
No sequence available.