PDB entry 1k4y

View 1k4y on RCSB PDB site
Description: Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine
Class: hydrolase
Keywords: hydrolase, esterase, side door, camptothecin, irinotecan
Deposited on 2001-10-09, released 2002-05-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.229
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: liver carboxylesterase
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed):
    • GB AAC39258 (0-533)
    Domains in SCOPe 2.07: d1k4ya_
  • Heterogens: 4PN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1k4yA (A:)
ppvvdtvhgkvlgkfvslegfaqpvavflgvpfakpplgslrfappqpaeswshvkntts
yppmcsqdavsghmlselftnrkeniplkfsedclylniytpadltkrgrlpvmvwihgg
glmvggastydglalsahenvvvvtiqyrlgiwgffstgdehsrgnwghldqvaalrwvq
dnianfggdpgsvtifgesaggqsvsilllspltknlfhraisesgvallsslfrkntks
laekiaieagcktttsavmvhclrqkteeelmevtlkmkfmaldlvgdpkentaflttvi
dgvllpkapaeilaekkynmlpymvginqqefgwiipmqmlgyplsegkldqktatellw
ksypivnvskeltpvatekylggtddpvkkkdlfldmladllfgvpsvnvarhhrdagap
tymyeyryrpsfssdmrpktvigdhgdeifsvlgapflkegateeeiklskmvmkywanf
arngnpngeglpqwpaydykegylqigattqaaqklkdkevafwtelwakeaar

    Sequence, based on observed residues (ATOM records): (download) 
    >1k4yA (A:)
ppvvdtvhgkvlgkfvslegfaqpvavflgvpfakpplgslrfappqpaeswshvkntts
yppmcsqdavsghmlselftnrkeniplkfsedclylniytpadltkrgrlpvmvwihgg
glmvggastydglalsahenvvvvtiqyrlgiwgffstgdehsrgnwghldqvaalrwvq
dnianfggdpgsvtifgesaggqsvsilllspltknlfhraisesgvallsslfrkntks
laekiaieagcktttsavmvhclrqkteeelmevtlkmkfmaldlvgdpkentaflttvi
dgvllpkapaeilaekkynmlpymvginqqefkldqktatellwksypivnvskeltpva
tekylggtddpvkkkdlfldmladllfgvpsvnvarhhrdagaptymyeyrhgdeifsvl
gapflkegateeeiklskmvmkywanfarngnpngeglpqwpaydykegylqigattqaa
qklkdkevafwtelwakeaar