PDB entry 1k2c

View 1k2c on RCSB PDB site
Description: Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
Class: hydrolase/hydrolase inhibitor
Keywords: hiv-1 protease, double mutants, dimer, inhibitor, x-ray diffraction
Deposited on 2001-09-26, released 2002-07-10
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.201
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: protease retropepsin
  Species: Human immunodeficiency virus 1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04587 (0-98)
    • engineered (6)
    • engineered (29)
    • engineered (32)
    • engineered (62)
    • engineered (66)
    • engineered (81)
    • engineered (94)
  Domains in SCOP 1.73: d1k2ca_
• Chain 'B':
  Compound: protease retropepsin
  Species: Human immunodeficiency virus 1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04587 (0-98)
    • engineered (6)
    • engineered (29)
    • engineered (32)
    • engineered (62)
    • engineered (66)
    • engineered (81)
    • engineered (94)
  Domains in SCOP 1.73: d1k2cb_
• Chain 'C':
  Compound: peptide inhibitor rv(dcl)fea(nle)
  
• Heterogens: NH2, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1k2cA (A:)
  pqitlwkrplvtikiggqlkealldtgadntvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpsniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1k2cB (B:)
  pqitlwkrplvtikiggqlkealldtgadntvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvlvgptpsniigrnlltqigatlnf
  

  
  
• Chain 'C':
  No sequence available.