PDB entry 1k25

View 1k25 on RCSB PDB site
Description: PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate
Class: membrane protein
Keywords: antibiotic resistance, clinical mutant, low-affinity penicillin-binding, MEMBRANE PROTEIN
Deposited on 2001-09-26, released 2001-10-31
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: 0.235
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: low-affinity PENICILLIN-BINDING PROTEIN 2X
    Species: Streptococcus pneumoniae [TaxId:1313]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O34006
      • engineered (298)
    Domains in SCOPe 2.05: d1k25a1, d1k25a2, d1k25a3, d1k25a4
  • Chain 'B':
    Compound: low-affinity PENICILLIN-BINDING PROTEIN 2X
    Species: Streptococcus pneumoniae [TaxId:1313]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k25b1, d1k25b2, d1k25b3, d1k25b4
  • Chain 'C':
    Compound: low-affinity PENICILLIN-BINDING PROTEIN 2X
    Species: Streptococcus pneumoniae [TaxId:1313]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k25c1, d1k25c2, d1k25c3, d1k25c4
  • Chain 'D':
    Compound: low-affinity PENICILLIN-BINDING PROTEIN 2X
    Species: Streptococcus pneumoniae [TaxId:1313]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k25d1, d1k25d2, d1k25d3, d1k25d4
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1k25A (A:)
hqitrtvpakrgtiydrngvpiaedatsynvyavidkkyksatgkilyvedaqfnkvaev
fhkyldmeesyvreqlsqpnlkqvsfgskgngityanmmaikkeletaevkgidfttspn
rsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgiityekdrvgniv
pgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilatt
qrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnsselk
iadattrdwdvneglttggmmtflqgfahssnvgmslleqkmgdatwldylkrfkfgvpt
rfgltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisaiyd
tnnqsvrksqkeivgnpvskeaasttrnhmilvgtdplygtmynhytgkpiitvpgqnva
vksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefat
pilerasamkeslnlqspaknldkvttessyampsikdispgelaealrrnivqpivvgt
gtkiketsveegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgs
vvqkqdvrtntaiknikkikltlgd

    Sequence, based on observed residues (ATOM records): (download) 
    >1k25A (A:)
qitrtvpakrgtiydrngvpiaedatsynvyavttspnrsypngqfassfiglaqlhene
dgsksllgtsgmesslnsilagtdgiitygnivpgtelvsqqtvdgkdvyttlssplqsf
metqmdaflekvkgkymtatlvsaktgeilattqrptfnadtkegitedfvwrdilyqsn
yepgsamkvmtlassidnntfpsgeyfnsselssnvgmslleqkmgdatwldylkrfkfg
vptrfgltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisa
iydtnnqsvrksqkeivgnpvskeaasttrnhmilvgtdpliitvpgqnvavksgtaqia
deknggylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefatpilerasam
keslnlqspaknldkvttessyampsikdispgelaealrrnivqpivvgtgtkiketsv
eegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgsvvqkqdvrt
ntaiknikkikltlgd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1k25B (B:)
hqitrtvpakrgtiydrngvpiaedatsynvyavidkkyksatgkilyvedaqfnkvaev
fhkyldmeesyvreqlsqpnlkqvsfgskgngityanmmaikkeletaevkgidfttspn
rsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgiityekdrvgniv
pgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilatt
qrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnsselk
iadattrdwdvneglttggmmtflqgfahssnvgmslleqkmgdatwldylkrfkfgvpt
rfgltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisaiyd
tnnqsvrksqkeivgnpvskeaasttrnhmilvgtdplygtmynhytgkpiitvpgqnva
vksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefat
pilerasamkeslnlqspaknldkvttessyampsikdispgelaealrrnivqpivvgt
gtkiketsveegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgs
vvqkqdvrtntaiknikkikltlgd

    Sequence, based on observed residues (ATOM records): (download) 
    >1k25B (B:)
hqitrtvpakrgtiydrngvpiaedatsynvyavisfgskgngityanmmaikkeletae
vkgidfttspnrsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgii
tpgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilat
tqrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnnvgm
slleqkmgdatwldylkrfkfgvptrfgltdeyagqlpadnivsiaqssfgqgisvtqtq
mlraftaiandgvmlepkfisaiydtnnqsvrksqkeivgnpvskeaasttrnhmilvgt
piitvpgqnvavksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpeh
ysgiqlgefatpilerasamkeslnlqspaknldkvttessyampsikdispgelaealr
rnivqpivvgtgtkiketsveegtnlapnqqvlllsdkveeipdmygwkketaetfakwl
dielefegsgsvvqkqdvrtntaiknikkikltlg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1k25C (C:)
hqitrtvpakrgtiydrngvpiaedatsynvyavidkkyksatgkilyvedaqfnkvaev
fhkyldmeesyvreqlsqpnlkqvsfgskgngityanmmaikkeletaevkgidfttspn
rsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgiityekdrvgniv
pgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilatt
qrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnsselk
iadattrdwdvneglttggmmtflqgfahssnvgmslleqkmgdatwldylkrfkfgvpt
rfgltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisaiyd
tnnqsvrksqkeivgnpvskeaasttrnhmilvgtdplygtmynhytgkpiitvpgqnva
vksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefat
pilerasamkeslnlqspaknldkvttessyampsikdispgelaealrrnivqpivvgt
gtkiketsveegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgs
vvqkqdvrtntaiknikkikltlgd

    Sequence, based on observed residues (ATOM records): (download) 
    >1k25C (C:)
qitrtvpakrgtiydrngvpiaedatsynvyavttspnrsypngqfassfiglaqlhene
dgsksllgtsgmesslnsilagtdgiitygnivpgtelvsqqtvdgkdvyttlssplqsf
metqmdaflekvkgkymtatlvsaktgeilattqrptfnadtkegitedfvwrdilyqsn
yepgsamkvmtlassidnntfpsgeyfnnvgmslleqkmgdatwldylkrfkfgvptrfg
ltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisaiydtnn
qsvrksqkeivgnpvskeaasttrnhmilvgtdpliitvpgqnvavksgtaqiadekngg
ylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefatpilerasamkeslnl
qspaknldkvttessyampsikdispgelaealrrnivqpivvgtgtkiketsveegtnl
apnqqvlllsdkveeipdmygwkketaetfakwldielefegsgsvvqkqdvrtntaikn
ikkikltlgd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1k25D (D:)
hqitrtvpakrgtiydrngvpiaedatsynvyavidkkyksatgkilyvedaqfnkvaev
fhkyldmeesyvreqlsqpnlkqvsfgskgngityanmmaikkeletaevkgidfttspn
rsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgiityekdrvgniv
pgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilatt
qrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnsselk
iadattrdwdvneglttggmmtflqgfahssnvgmslleqkmgdatwldylkrfkfgvpt
rfgltdeyagqlpadnivsiaqssfgqgisvtqtqmlraftaiandgvmlepkfisaiyd
tnnqsvrksqkeivgnpvskeaasttrnhmilvgtdplygtmynhytgkpiitvpgqnva
vksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpehysgiqlgefat
pilerasamkeslnlqspaknldkvttessyampsikdispgelaealrrnivqpivvgt
gtkiketsveegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgs
vvqkqdvrtntaiknikkikltlgd

    Sequence, based on observed residues (ATOM records): (download) 
    >1k25D (D:)
hqitrtvpakrgtiydrngvpiaedatsynvyavisfgskgngityanmmaikkeletae
vkgidfttspnrsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtdgii
tpgtelvsqqtvdgkdvyttlssplqsfmetqmdaflekvkgkymtatlvsaktgeilat
tqrptfnadtkegitedfvwrdilyqsnyepgsamkvmtlassidnntfpsgeyfnnvgm
slleqkmgdatwldylkrfkfgvptrfgltdeyagqlpadnivsiaqssfgqgisvtqtq
mlraftaiandgvmlepkfisaiydtnnqsvrksqkeivgnpvskeaasttrnhmilvgt
piitvpgqnvavksgtaqiadeknggylvgstnyifsavtmnpaenpdfilyvtvqqpeh
ysgiqlgefatpilerastessyampsikdispgelaealrrnivqpivvgtgtkikets
veegtnlapnqqvlllsdkveeipdmygwkketaetfakwldielefegsgsvvqkqdvr
tntaiknikkikltlg