PDB entry 1jwt

View 1jwt on RCSB PDB site
Description: crystal structure of thrombin in complex with a novel bicyclic lactam inhibitor
Class: hydrolase
Keywords: hydrolase
Deposited on 2001-09-05, released 2002-02-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.182
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Prothrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-294)
      • cloning artifact (295-304)
    Domains in SCOPe 2.06: d1jwta1, d1jwta2
  • Heterogens: BLI

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1jwtA (A:)
tfgsgeadcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspq
ellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismleki
yihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnl
ketwtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegd
sggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfgedfeei
peeyl

    Sequence, based on observed residues (ATOM records): (download) 
    >1jwtA (A:)
tfgsgeadcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspq
ellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismleki
yihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnl
ketwgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfv
mkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfgedfeeipeeyl