PDB entry 1ju6

View 1ju6 on RCSB PDB site
Description: Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate
Class: transferase
Keywords: antifolate, dTMP synthesis, drug resistance, cancer, TRANSFERASE
Deposited on 2001-08-23, released 2001-09-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.89 Å
R-factor: 0.236
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (Start-312)
      • engineered (45)
    Domains in SCOPe 2.08: d1ju6a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (Start-312)
      • engineered (45)
    Domains in SCOPe 2.08: d1ju6b_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (Start-312)
      • engineered (45)
    Domains in SCOPe 2.08: d1ju6c_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (Start-312)
      • engineered (45)
    Domains in SCOPe 2.08: d1ju6d_
  • Heterogens: PO4, UMP, LYA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ju6A (A:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvekddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >1ju6A (A:)
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ju6B (B:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvekddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >1ju6B (B:)
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ju6C (C:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvekddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >1ju6C (C:)
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1ju6D (D:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvekddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >1ju6D (D:)
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav