PDB entry 1jtq
View 1jtq on RCSB PDB site
Description: E. coli TS Complex with dUMP and the Pyrrolo(2,3-d)pyrimidine-based Antifolate LY341770
Class: transferase
Keywords: antifolate, cancer, drug resistance, dTMP synthesis, TRANSFERASE
Deposited on
2001-08-21, released
2001-09-19
The last revision prior to the SCOPe 2.07 freeze date was dated
2017-10-11, with a file datestamp of
2017-10-06.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Thymidylate synthase
Species: Escherichia coli [TaxId:562]
Gene: thyA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1jtqa_ - Chain 'B':
Compound: Thymidylate synthase
Species: Escherichia coli [TaxId:562]
Gene: thyA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1jtqb_ - Heterogens: UMP, LY3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1jtqA (A:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1jtqB (B:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai