PDB entry 1jlc

View 1jlc on RCSB PDB site
Description: crystal structure of y181c mutant hiv-1 reverse transcriptase in complex with pett-2
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, pett-2, drug resistance mutations, drug design
Deposited on 2001-07-16, released 2001-10-03
The last revision prior to the SCOP 1.73 freeze date was dated 2004-01-06, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.225
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hiv-1 rt a-chain
    Species: Human immunodeficiency virus type 1 (isolate HXB2)
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-End)
      • engineered (180)
      • oxidized cys (279)
    Domains in SCOP 1.73: d1jlca1, d1jlca2
  • Chain 'B':
    Compound: hiv-1 rt b-chain
    Species: Human immunodeficiency virus type 1 (isolate HXB2)
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (180)
    Domains in SCOP 1.73: d1jlcb_
  • Heterogens: FTC

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1jlcA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
cqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1jlcA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsiiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivicqymddlyvgsd
leigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdsw
tvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilke
pvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteav
qkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqleke
pivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalqdsgle
vnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1jlcB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
cqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1jlcB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwehpaglkkkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivicqymddlyvgs
dleigqhrtkieelrqhllrwgelhpdkwtvqpivlpekdswtvndiqklvgklnwasqi
ypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiq
kqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfk
lpiqketwetwwteywqatwipewefvntpplvklwyqleke