PDB entry 1jl0

View 1jl0 on RCSB PDB site
Description: Structure of a Human S-Adenosylmethionine Decarboxylase Self-processing Ester Intermediate and Mechanism of Putrescine Stimulation of Processing as Revealed by the H243A Mutant
Class: lyase
Keywords: spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl, ester intermediate, hydroxyalanine
Deposited on 2001-07-13, released 2001-08-22
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.215
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: s-adenosylmethionine decarboxylase proenzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17707
      • engineered (242)
    Domains in SCOPe 2.01: d1jl0a_
  • Chain 'B':
    Compound: s-adenosylmethionine decarboxylase proenzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17707
      • engineered (242)
    Domains in SCOPe 2.01: d1jl0b_
  • Heterogens: PUT, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1jl0A (A:)
meaahffegtekllevwfsrqqpdanqgsgdlrtiprsewdillkdvqcsiisvtktdkq
eayvlsessmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkp
shqgyphrnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleil
mseldpavmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtyw
tiaitpepefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcrtvlaspq
kiegfkrldcqsamfndynfvftsfakkqqqqqs

    Sequence, based on observed residues (ATOM records): (download) 
    >1jl0A (A:)
hffegtekllevwfsrqqgsgdlrtiprsewdillkdvqcsiisvtktdkqeayvlsess
mfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyphrn
fqeeieflnaifpngagycmgrmnsdcwylytldfpvisqpdqtleilmseldpavmdqf
ymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtiaitpepefsy
vsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcqkiegfkrldcqsamfndyn
fvftsfakkq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1jl0B (B:)
meaahffegtekllevwfsrqqpdanqgsgdlrtiprsewdillkdvqcsiisvtktdkq
eayvlsessmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkp
shqgyphrnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleil
mseldpavmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtyw
tiaitpepefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcrtvlaspq
kiegfkrldcqsamfndynfvftsfakkqqqqqs

    Sequence, based on observed residues (ATOM records): (download) 
    >1jl0B (B:)
hffegtekllevwfsrqgsgdlrtiprsewdillkdvqcsiisvtktdkqeayvlsessm
fvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyphrnf
qeeieflnaifpngagycmgrmnsdcwylytldfrvisqpdqtleilmseldpavmdqfy
mkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtiaitpepefsyv
sfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcpqkiegfkrldcqsamfndyn
fvftsfakkqq