PDB entry 1ivh

View 1ivh on RCSB PDB site
Description: structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity
Class: oxidoreductase
Keywords: oxidoreductase, acyl-coa dehydrogenase, flavoprotein, isovaleryl-coa, isovaleric acidemia
Deposited on 1997-05-15, released 1998-05-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.207
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isovaleryl-coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: IVD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1ivha1, d1ivha2
  • Chain 'B':
    Compound: isovaleryl-coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: IVD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1ivhb1, d1ivhb2
  • Chain 'C':
    Compound: isovaleryl-coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: IVD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1ivhc1, d1ivhc2
  • Chain 'D':
    Compound: isovaleryl-coa dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: IVD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1ivhd1, d1ivhd2
  • Heterogens: FAD, COS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ivhA (A:)
hsllpvddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgv
lgitapvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkeky
lpklisgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivya
ktdlaavpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghe
nkgvyvlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadm
ytrlmacrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfp
mgrflrdaklyeigagtsevrrlvigrafnadfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1ivhA (A:)
vddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgvlgita
pvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkekylpkli
sgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivyaktdla
avpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghenkgvy
vlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadmytrlm
acrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfpmgrfl
rdaklyeigagtsevrrlvigrafnad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ivhB (B:)
hsllpvddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgv
lgitapvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkeky
lpklisgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivya
ktdlaavpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghe
nkgvyvlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadm
ytrlmacrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfp
mgrflrdaklyeigagtsevrrlvigrafnadfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1ivhB (B:)
vddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgvlgita
pvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkekylpkli
sgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivyaktdla
avpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghenkgvy
vlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadmytrlm
acrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfpmgrfl
rdaklyeigagtsevrrlvigrafnad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ivhC (C:)
hsllpvddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgv
lgitapvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkeky
lpklisgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivya
ktdlaavpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghe
nkgvyvlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadm
ytrlmacrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfp
mgrflrdaklyeigagtsevrrlvigrafnadfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1ivhC (C:)
vddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgvlgita
pvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkekylpkli
sgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivyaktdla
avpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghenkgvy
vlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadmytrlm
acrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfpmgrfl
rdaklyeigagtsevrrlvigrafnad

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1ivhD (D:)
hsllpvddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgv
lgitapvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkeky
lpklisgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivya
ktdlaavpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghe
nkgvyvlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadm
ytrlmacrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfp
mgrflrdaklyeigagtsevrrlvigrafnadfh

    Sequence, based on observed residues (ATOM records): (download) 
    >1ivhD (D:)
vddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgvlgita
pvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkekylpkli
sgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivyaktdla
avpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghenkgvy
vlmsgldlerlvlaggplglmqavldhtipylhvreafgqkighfqlmqgkmadmytrlm
acrqyvynvakacdeghctakdcagvilysaecatqvaldgiqcfggngyindfpmgrfl
rdaklyeigagtsevrrlvigrafnad