PDB entry 1i7m

View 1i7m on RCSB PDB site
Description: human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with 4-amidinoindan-1-one-2'-amidinohydrazone
Class: lyase
Keywords: Spermidine biosynthesis, Lyase, Decarboxylase, Pyruvate, S-ADENOSYLMETHIONINE, SANDWICH, ALLOSTERIC ENZYME, PYRUVOYL
Deposited on 2001-03-09, released 2001-08-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: s-adenosylmethionine decarboxylase alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17707
      • see remark 999 (0)
      • modified residue (2)
      • modified residue (50)
      • modified residue (81)
      • modified residue (84)
      • modified residue (113)
      • modified residue (121)
      • modified residue (126)
      • modified residue (154)
      • modified residue (162)
      • modified residue (165)
      • modified residue (246)
    Domains in SCOPe 2.08: d1i7m.1
  • Chain 'B':
    Compound: s-adenosylmethionine decarboxylase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i7m.1
  • Chain 'C':
    Compound: s-adenosylmethionine decarboxylase alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17707 (0-End)
      • see remark 999 (0)
      • modified residue (2)
      • modified residue (50)
      • modified residue (81)
      • modified residue (84)
      • modified residue (113)
      • modified residue (121)
      • modified residue (126)
      • modified residue (154)
      • modified residue (162)
      • modified residue (165)
      • modified residue (246)
    Domains in SCOPe 2.08: d1i7m.2
  • Chain 'D':
    Compound: s-adenosylmethionine decarboxylase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i7m.2
  • Heterogens: PUT, CG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1i7mA (A:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleilmseldpa
vmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpe
pefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcrtvlaspqkiegfkr
ldcqsamfndynfvftsfakkqqqqqs

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7mA (A:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfqpdqtleilmseldpavmdqfym
kdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpepefsyvs
fetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcpqkiegfkrldcqsamfndynf
vftsfakkq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1i7mB (B:)
meaahffegtekllevwfsrqqpdanqgsgdlrtiprsewdillkdvqcsiisvtktdkq
eayvlse

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7mB (B:)
ahffegtekllevwfsrgsgdlrtiprsewdillkdvqcsiisvtktdkqeayvlse

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1i7mC (C:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleilmseldpa
vmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpe
pefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcrtvlaspqkiegfkr
ldcqsamfndynfvftsfakkqqqqqs

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7mC (C:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfqpdqtleilmseldpavmdqfym
kdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpepefsyvs
fetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcpqkiegfkrldcqsamfndynf
vftsfakkq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1i7mD (D:)
meaahffegtekllevwfsrqqpdanqgsgdlrtiprsewdillkdvqcsiisvtktdkq
eayvlse

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7mD (D:)
hffegtekllevwfsgsgdlrtiprsewdillkdvqcsiisvtktdkqeayvlse