PDB entry 1i7c

View 1i7c on RCSB PDB site
Description: human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Class: lyase
Keywords: Spermidine biosynthesis, Lyase, Decarboxylase, Pyruvate, S-ADENOSYLMETHIONINE, SANDWICH, ALLOSTERIC ENZYME, PYRUVOYL
Deposited on 2001-03-08, released 2001-08-22
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.176
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: s-adenosylmethionine decarboxylase alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17707 (0-End)
      • see remark 999 (0)
    Domains in SCOPe 2.01: d1i7c.1
  • Chain 'B':
    Compound: s-adenosylmethionine decarboxylase beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1i7c.1
  • Heterogens: PUT, MGB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1i7cA (A:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleilmseldpa
vmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpe
pefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqsskcrtvlaspqkiegfkr
ldcqsamfndynfvftsfakkqqqqqs

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7cA (A:)
xsmfvskrrfilktcgttlllkalvpllklardysgfdsiqsffysrknfmkpshqgyph
rnfqeeieflnaifpngagycmgrmnsdcwylytldfpesrvisqpdqtleilmseldpa
vmdqfymkdgvtakdvtresgirdlipgsvidatmfnpcgysmngmksdgtywtihitpe
pefsyvsfetnlsqtsyddlirkvvevfkpgkfvttlfvnqstvlaspqkiegfkrldcq
samfndynfvftsfakkq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1i7cB (B:)
meaahffegtekllevwfsrqqpdanqgsgdlrtiprsewdillkdvqcsiisvtktdkq
eayvlse

    Sequence, based on observed residues (ATOM records): (download) 
    >1i7cB (B:)
ahffegtekllevwfsrqqpqgsgdlrtiprsewdillkdvqcsiisvtktdkqeayvls
e