PDB entry 1i43

View 1i43 on RCSB PDB site
Description: cystathionine gamma-synthase in complex with the inhibitor ppca
Class: lyase
Keywords: PLP-dependent enzyme, homotetramer, inhibitor complex, PPCA, LYASE
Deposited on 2001-02-19, released 2001-09-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.236
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43a_
  • Chain 'B':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43b_
  • Chain 'C':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43c_
  • Chain 'D':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43d_
  • Chain 'E':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43e_
  • Chain 'F':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43f_
  • Chain 'G':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43g_
  • Chain 'H':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43h_
  • Chain 'I':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43i_
  • Chain 'J':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43j_
  • Chain 'K':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43k_
  • Chain 'L':
    Compound: cystathionine gamma-synthase
    Species: Nicotiana tabacum [TaxId:4097]
    Gene: METB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1i43l_
  • Heterogens: PLP, PMC

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1i43A (A:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43A (A:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1i43B (B:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43B (B:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1i43C (C:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43C (C:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1i43D (D:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43D (D:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1i43E (E:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43E (E:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1i43F (F:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43F (F:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1i43G (G:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43G (G:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1i43H (H:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43H (H:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1i43I (I:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43I (I:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >1i43J (J:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43J (J:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >1i43K (K:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43K (K:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1i43L (L:)
    makavdaaaaaaaaiapvdttvvnedvalvenetcndqnvqfdslpsmkyasflnsdgsv
    aihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeygrygnpttvvle
    ekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrifietilpkmgit
    atvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchekgalvcidgtfa
    tplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhhilggalnpnaa
    yliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehhiakkqmtgfgg
    avsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsqsdrakygimdn
    lvrfsfgvedfddlkadilqaldsi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1i43L (L:)
    yasflnsdgsvaihagerlgrgivtdaittpvvntsayffnktselidfkekrrasfeyg
    rygnpttvvleekisalegaestllmasgmcastvmllalvpagghivtttdcyrktrif
    ietilpkmgitatvidpadvgalelalnqkkvnlfftesptnpflrcvdielvsklchek
    galvcidgtfatplnqkalalgadlvlhsatkflgghndvlagcisgplklvseirnlhh
    ilggalnpnaayliirgmktlhlrvqqqnstalrmaeileahpkvrhvyypglqshpehh
    iakkqmtgfggavsfevdgdllttakfvdalkipyiapsfggcesivdqpaimsywdlsq
    sdrakygimdnlvrfsfgvedfddlkadilqaldsi