PDB entry 1i3l

View 1i3l on RCSB PDB site
Description: molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase
Class: isomerase
Keywords: epimerase galactosemia short-chain dehydrogenase, ISOMERASE
Deposited on 2001-02-15, released 2001-06-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: UDP-glucose 4-epimerase
    Species: Homo sapiens [TaxId:9606]
    Gene: HGALE
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14376 (Start-347)
      • engineered (93)
    Domains in SCOPe 2.08: d1i3la_
  • Chain 'B':
    Compound: UDP-glucose 4-epimerase
    Species: Homo sapiens [TaxId:9606]
    Gene: HGALE
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14376
      • engineered (93)
    Domains in SCOPe 2.08: d1i3lb_
  • Heterogens: GDU, CL, MG, NAD, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1i3lA (A:)
maekvlvtggagyigshtvlelleagylpvvidnfhnafrgggslpeslrrvqeltgrsv
efeemdildqgalqrlfkkysfmavihfaglkamgesvqkpldyyrvnltgtiqlleimk
ahgvknlvfsssatvygnpqylpldeahptggctnpygkskffieemirdlcqadktwnv
vllryfnptgahasgcigedpqgipnnlmpyvsqvaigrrealnvfgndydtedgtgvrd
yihvvdlakghiaalrklkeqcgcriynlgtgtgysvlqmvqamekasgkkipykvvarr
egdvaacyanpslaqeelgwtaalgldrmcedlwrwqkqnpsgfgtqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1i3lA (A:)
aekvlvtggagyigshtvlelleagylpvvidnfhnafrgggslpeslrrvqeltgrsve
feemdildqgalqrlfkkysfmavihfaglkamgesvqkpldyyrvnltgtiqlleimka
hgvknlvfsssatvygnpqylpldeahptggctnpygkskffieemirdlcqadktwnvv
llryfnptgahasgcigedpqgipnnlmpyvsqvaigrrealnvfgndydtedgtgvrdy
ihvvdlakghiaalrklkeqcgcriynlgtgtgysvlqmvqamekasgkkipykvvarre
gdvaacyanpslaqeelgwtaalgldrmcedlwrwqkqnpsgfgtqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1i3lB (B:)
maekvlvtggagyigshtvlelleagylpvvidnfhnafrgggslpeslrrvqeltgrsv
efeemdildqgalqrlfkkysfmavihfaglkamgesvqkpldyyrvnltgtiqlleimk
ahgvknlvfsssatvygnpqylpldeahptggctnpygkskffieemirdlcqadktwnv
vllryfnptgahasgcigedpqgipnnlmpyvsqvaigrrealnvfgndydtedgtgvrd
yihvvdlakghiaalrklkeqcgcriynlgtgtgysvlqmvqamekasgkkipykvvarr
egdvaacyanpslaqeelgwtaalgldrmcedlwrwqkqnpsgfgtqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1i3lB (B:)
aekvlvtggagyigshtvlelleagylpvvidnfhnafrgggslpeslrrvqeltgrsve
feemdildqgalqrlfkkysfmavihfaglkamgesvqkpldyyrvnltgtiqlleimka
hgvknlvfsssatvygnpqylpldeahptggctnpygkskffieemirdlcqadktwnvv
llryfnptgahasgcigedpqgipnnlmpyvsqvaigrrealnvfgndydtedgtgvrdy
ihvvdlakghiaalrklkeqcgcriynlgtgtgysvlqmvqamekasgkkipykvvarre
gdvaacyanpslaqeelgwtaalgldrmcedlwrwqkqnpsgfgt