PDB entry 1hwl

View 1hwl on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with rosuvastatin (formally known as zd4522)
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOP 1.57 freeze date was dated 2001-05-11, with a file datestamp of 2001-05-11.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.219
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hwlA (A:)
prpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsirrqllsk
klsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegc
lvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikea
fdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqil
avsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsa
magsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsie
igtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwlA (A:)
prpneecflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylp
yrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcrai
glgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqk
lhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkp
aainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynaha
anivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllp
qqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hwlB (B:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hwlC (C:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hwlD (D:)
ykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipv
gvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpr
acdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmn
miskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvr
evlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssnci
tlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarql
arivcgtvmagelslmaalaag