PDB entry 1hwl

View 1hwl on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with rosuvastatin (formally known as zd4522)
Class: oxidoreductase
Keywords: protein-inhibitor complex, oxidoreductase
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.219
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwla1, d1hwla2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwlb1, d1hwlb2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwlc1, d1hwlc2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwld1, d1hwld2
  • Heterogens: ADP, FBI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hwlA (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwlA (A:)
prpneecflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylp
yrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcrai
glgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqk
lhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkp
aainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynaha
anivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllp
qqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hwlB (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwlB (B:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hwlC (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwlC (C:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hwlD (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwlD (D:)
ykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipv
gvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpr
acdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmn
miskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvr
evlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssnci
tlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarql
arivcgtvmagelslmaalaag