PDB entry 1hwk

View 1hwk on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with atorvastatin
Class: oxidoreductase
Keywords: protein-inhibitor complex, oxidoreductase
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: 0.212
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwka1, d1hwka2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwkb1, d1hwkb2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwkc1, d1hwkc2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hwkd1, d1hwkd2
  • Heterogens: ADP, 117, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hwkA (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwkA (A:)
prpneecllsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylp
yrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcrai
glgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqk
lhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkp
aainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynaha
anivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllp
qqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaagh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hwkB (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwkB (B:)
sdaeiiqlvnaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgacc
envigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladg
mtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirf
qsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvv
ceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqd
aaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgac
kdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hwkC (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwkC (C:)
lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
rvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagr
nlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwieg
rgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiy
iacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqml
gvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hwkD (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwkD (D:)
sdaeiiqletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigy
mpipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpv
vrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgd
amgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavip
akvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvg
ssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpge
narqlarivcgtvmagelslmaalaag