PDB entry 1hwi

View 1hwi on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with fluvastatin
Class: oxidoreductase
Keywords: protein-inhibitor complex, oxidoreductase
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-05-06, with a file datestamp of 2015-05-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.07: d1hwia1, d1hwia2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.07: d1hwib1, d1hwib2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1hwic1, d1hwic2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1hwid1, d1hwid2
  • Heterogens: ADP, 115, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hwiA (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwiA (A:)
lsdaeiiqlvnletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccen
vigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmt
rgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqs
rsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvce
avipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaa
qnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackd
npgenarqlarivcgtvmagelslmaalaaghl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hwiB (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwiB (B:)
lsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynysl
vmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggass
rvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagr
nlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwieg
rgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiy
iacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqml
gvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hwiC (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwiC (C:)
ergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplclde
kefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkaw
letsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekal
sklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteam
ievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptn
edlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvma
gelslmaalaaghl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hwiD (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hwiD (D:)
thergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcl
dekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevk
awletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtek
alsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttte
amievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgp
tnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtv
magelslmaalaag