PDB entry 1hwh

View 1hwh on RCSB PDB site
Description: 1:1 complex of human growth hormone mutant g120r with its soluble binding protein
Class: complex (hormone/receptor)
Keywords: cytokine, hormone, receptor, hematopoietic, complex (hormone/receptor)
Deposited on 1996-11-13, released 1997-11-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.215
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: growth hormone
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01241 (0-190)
      • engineered (119)
    Domains in SCOPe 2.08: d1hwha_
  • Chain 'B':
    Compound: growth hormone binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1hwhb1, d1hwhb2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1hwhA (A:)
    fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
    psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
    iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
    qcrsvegscgf
    

    Sequence, based on observed residues (ATOM records): (download)
    >1hwhA (A:)
    fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
    psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleer
    iqtlmgrledgsprtgqifkqtyskfddallknygllycfrkdmdkvetflrivqcrsve
    gscgf
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1hwhB (B:)
    fsgseataailsrapwslqsvnpglktnsskepkftkcrsperetfschwtdevhhgtkn
    lgpiqlfytrrntqewtqewkecpdyvsagenscyfnssftsiwipycikltsnggtvde
    kcfsvdeivqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqyke
    vnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqms
    

    Sequence, based on observed residues (ATOM records): (download)
    >1hwhB (B:)
    epkftkcrsperetfschwtdpiqlfytrrntqewtqewkecpdyvsagenscyfnssft
    siwipycikltsnggtvdekcfsvdeivqpdppialnwtllnvsltgihadiqvrweapr
    nadiqkgwmvleyelqykevnetkwkmmdpilttsvpvyslkvdkeyevrvrskqrnsgn
    ygefsevlyvtlpqms