PDB entry 1hw9

View 1hw9 on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with simvastatin
Class: oxidoreductase
Keywords: protein-inhibitor complex, oxidoreductase
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: 0.222
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hw9a1, d1hw9a2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hw9b1, d1hw9b2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hw9c1, d1hw9c2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOPe 2.08: d1hw9d1, d1hw9d2
  • Heterogens: ADP, SIM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hw9A (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw9A (A:)
prpneeckflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqyl
pyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcra
iglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlq
klhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkk
paainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynah
aanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnll
pqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hw9B (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw9B (B:)
sdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslqylpyrdynyslv
mgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassr
vladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrn
lyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegr
gksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyi
acgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlg
vqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hw9C (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw9C (C:)
sdaeiiaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvi
gympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrg
pvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrs
gdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceav
ipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqn
vgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnp
genarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hw9D (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw9D (D:)
daeiiqaykletliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvi
gympipvgvagplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrg
pvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrs
gdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceav
ipakvvrevlkttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqn
vgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnp
genarqlarivcgtvmagelslmaalaa