PDB entry 1hw8

View 1hw8 on RCSB PDB site
Description: complex of the catalytic portion of human hmg-coa reductase with compactin (also known as mevastatin)
Class: oxidoreductase
Keywords: protein-inhibitor complex
Deposited on 2001-01-09, released 2001-05-11
The last revision prior to the SCOP 1.75 freeze date was dated 2001-05-11, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.191
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.75: d1hw8a1, d1hw8a2
  • Chain 'B':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035
      • engineered (63)
    Domains in SCOP 1.75: d1hw8b1, d1hw8b2
  • Chain 'C':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hw8c1, d1hw8c2
  • Chain 'D':
    Compound: hmg-coa reductase
    Species: HOMO SAPIENS
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hw8d1, d1hw8d2
  • Heterogens: 114, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hw8A (A:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw8A (A:)
eprpneeclsdaeiiqlvnpaykletliethergvsirrqllskklsepsslqylpyrdy
nyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgcraiglgg
gassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfarlqklhts
iagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctdkkpaain
wiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggynahaaniv
taiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtnllpqqac
lqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaagh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hw8B (B:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw8B (B:)
rpneeclqikflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepsslq
ylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrgc
raiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfar
lqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyctd
kkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggyn
ahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggtn
llpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hw8C (C:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw8C (C:)
hergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcld
ekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevka
wletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgteka
lsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlktttea
mievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgpt
nedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvm
agelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hw8D (D:)
gamassvlvtqepeielpreprpneeclqilgnaekgakflsdaeiiqlvnakhipaykl
etliethergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgva
gplcldekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracd
saevkawletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmis
kgtekalsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevl
kttteamievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlm
easgptnedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlari
vcgtvmagelslmaalaaghlvkshmihnrskinlqdlqgactkkta

    Sequence, based on observed residues (ATOM records): (download) 
    >1hw8D (D:)
hergvsirrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcld
ekefqvpmattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevka
wletsegfavikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgteka
lsklheyfpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlktttea
mievninknlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgpt
nedlyisctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvm
agelslmaalaa