PDB entry 1hw4
View 1hw4 on RCSB PDB site
Description: structure of thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
Class: transferase
Keywords: Thymidylate Synthase, Methyltransferase, TRANSFERASE
Deposited on
2001-01-09, released
2001-01-24
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.06 Å
R-factor: 0.224
AEROSPACI score: 0.38
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Thymidylate synthase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P04818
- modified residue (84)
- modified residue (221)
- conflict (240)
Domains in SCOPe 2.06: d1hw4a_ - Heterogens: SO4, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1hw4A (A:)
mghhhhhhdtdipttenltfqgacrlvancrdvrcrrllrnvmpvagselprrplppaaq
erdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkr
vfwkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfq
wrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchal
cqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiy
lnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav
Sequence, based on observed residues (ATOM records): (download)
>1hw4A (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvgdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidt
iktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfni
asyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvek
iddfkaedfqiegynphptikme