PDB entry 1hlt

View 1hlt on RCSB PDB site
Description: the structure of a nonadecapeptide of the fifth egf domain of thrombomodulin complexed with thrombin
Class: hydrolase/hydrolase inhibitor
Keywords: SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 1994-08-28, released 1994-12-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.146
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1hlt.1
  • Chain 'J':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1hlt.2
  • Chain 'K':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1hlt.2
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1hlt.1
  • Chain 'R':
    Compound: thrombomodulin
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 0G6, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1hltH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hltH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtgqpsvlqvvnlpiverpvckdstriritdnm
fcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfr
lkkwiqkvidq

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hltJ (J:)
adcglrplfekksledkterellesyi

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1hltK (K:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hltK (K:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtgqpsvlqvvnlpiverpvckdstriritdnm
fcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfr
lkkwiqkvidq

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hltL (L:)
adcglrplfekksledkterellesyi

  • Chain 'R':
    No sequence available.