PDB entry 1hlt

View 1hlt on RCSB PDB site
Description: the structure of a nonadecapeptide of the fifth egf domain of thrombomodulin complexed with thrombin
Class: complex(serine proteinase/inhibitor)
Keywords: complex(serine proteinase/inhibitor)
Deposited on 1994-08-28, released 1994-12-20
The last revision prior to the SCOP 1.75 freeze date was dated 1994-12-20, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.146
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hlt.1
  • Chain 'I':
    Compound: ppack with chloromethylketone replaced by a methylene group
  • Chain 'J':
    Compound: alpha-thrombin (small subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hlt.2
  • Chain 'K':
    Compound: alpha-thrombin (large subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hlt.2
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hlt.1
  • Chain 'M':
    Compound: ppack with chloromethylketone replaced by a methylene group
  • Chain 'R':
    Compound: thrombomodulin
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CH2, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1hltH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hltH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtgqpsvlqvvnlpiverpvckdstriritdnm
fcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfr
lkkwiqkvidq

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hltJ (J:)
adcglrplfekksledkterellesyi

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1hltK (K:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hltK (K:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtgqpsvlqvvnlpiverpvckdstriritdnm
fcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfr
lkkwiqkvidq

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1hltL (L:)
adcglrplfekksledkterellesyi

  • Chain 'M':
    No sequence available.

  • Chain 'R':
    No sequence available.