PDB entry 1hkb

View 1hkb on RCSB PDB site
Description: crystal structure of recombinant human brain hexokinase type I complexed with glucose and glucose-6-phosphate
Class: phosphotransferase
Keywords: phosphotransferase, glycolysis, allosteric enzyme, glucose, glucose-6-phosphate
Deposited on 1997-12-01, released 1998-06-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-08-04, with a file datestamp of 2009-07-31.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.2
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: d-glucose 6-phosphotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1hkba1, d1hkba2, d1hkba3, d1hkba4
  • Chain 'B':
    Compound: d-glucose 6-phosphotransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1hkbb1, d1hkbb2, d1hkbb3, d1hkbb4
  • Heterogens: BGC, G6P, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hkbA (A:)
miaaqllayyftelkddqvkkidkylyamrlsdetlidimtrfrkemknglsrdfnptat
vkmlptfvrsipdgsekgdfialdlggssfrilrvqvnheknqnvhmesevydtpenivh
gsgsqlfdhvaeclgdfmekrkikdkklpvgftfsfpcqqskideailitwtkrfkasgv
egadvvkllnkaikkrgdydanivavvndtvgtmmtcgyddqhcevgliigtgtnacyme
elrhidlvegdegrmcintewgafgddgsledirtefdreidrgslnpgkqlfekmvsgm
ylgelvrlilvkmakegllfegritpelltrgkfntsdvsaieknkeglhnakeiltrlg
vepsdddcvsvqhvctivsfrsanlvaatlgailnrlrdnkgtprlrttvgvdgslykth
pqysrrfhktlrrlvpdsdvrfllsesgsgkgaamvtavayrlaeqhrqieetlahfhlt
kdmllevkkrmraemelglrkqthnnavvkmlpsfvrrtpdgtengdflaldlggtnfrv
llvkirsgkkrtvemhnkiyaipieimqgtgeelfdhivscisdfldymgikgprmplgf
tfsfpcqqtsldagilitwtkgfkatdcvghdvvtllrdaikrreefdldvvavvndtvg
tmmtcayeeptcevglivgtgsnacymeemknvemvegdqgqmcinmewgafgdngcldd
irthydrlvdeyslnagkqryekmisgmylgeivrnilidftkkgflfrgqisetlktrg
ifetkflsqiesdrlallqvrailqqlglnstcddsilvktvcgvvsrraaqlcgagmaa
vvdkirenrgldrlnvtvgvdgtlyklhphfsrimhqtvkelspkcnvsfllsedgsgkg
aalitavgvrlrteass

    Sequence, based on observed residues (ATOM records): (download) 
    >1hkbA (A:)
ddqvkkidkylyamrlsdetlidimtrfrkemknglsrdfnptatvkmlptfvrsipdgs
ekgdfialdlggssfrilrvqvnheknqnvhmesevydtpenivhgsgsqlfdhvaeclg
dfmekrkikdkklpvgftfsfpcqqskideailitwtkrfkasgvegadvvkllnkaikk
rgdydanivavvndtvgtmmtcgyddqhcevgliigtgtnacymeelrhidlvegdegrm
cintewgafgddgsledirtefdreidrgslnpgkqlfekmvsgmylgelvrlilvkmak
egllfegritpelltrgkfntsdvsaieknkeglhnakeiltrlgvepsdddcvsvqhvc
tivsfrsanlvaatlgailnrlrdnkgtprlrttvgvdgslykthpqysrrfhktlrrlv
pdsdvrfllsesgsgkgaamvtavayrlaeqhrqieetlahfhltkdmllevkkrmraem
elglrkqthnnavvkmlpsfvrrtpdgtengdflaldlggtnfrvllvkirsgkkrtvem
hnkiyaipieimqgtgeelfdhivscisdfldymgikgprmplgftfsfpcqqtsldagi
litwtkgfkatdcvghdvvtllrdaikrreefdldvvavvndtvgtmmtcayeeptcevg
livgtgsnacymeemknvemvegdqgqmcinmewgafgdngclddirthydrlvdeysln
agkqryekmisgmylgeivrnilidftkkgflfrgqisetlktrgifetkflsqiesdrl
allqvrailqqlglnstcddsilvktvcgvvsrraaqlcgagmaavvdkirenrgldrln
vtvgvdgtlyklhphfsrimhqtvkelspkcnvsfllsedgsgkgaalitavgvrlrte

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hkbB (B:)
miaaqllayyftelkddqvkkidkylyamrlsdetlidimtrfrkemknglsrdfnptat
vkmlptfvrsipdgsekgdfialdlggssfrilrvqvnheknqnvhmesevydtpenivh
gsgsqlfdhvaeclgdfmekrkikdkklpvgftfsfpcqqskideailitwtkrfkasgv
egadvvkllnkaikkrgdydanivavvndtvgtmmtcgyddqhcevgliigtgtnacyme
elrhidlvegdegrmcintewgafgddgsledirtefdreidrgslnpgkqlfekmvsgm
ylgelvrlilvkmakegllfegritpelltrgkfntsdvsaieknkeglhnakeiltrlg
vepsdddcvsvqhvctivsfrsanlvaatlgailnrlrdnkgtprlrttvgvdgslykth
pqysrrfhktlrrlvpdsdvrfllsesgsgkgaamvtavayrlaeqhrqieetlahfhlt
kdmllevkkrmraemelglrkqthnnavvkmlpsfvrrtpdgtengdflaldlggtnfrv
llvkirsgkkrtvemhnkiyaipieimqgtgeelfdhivscisdfldymgikgprmplgf
tfsfpcqqtsldagilitwtkgfkatdcvghdvvtllrdaikrreefdldvvavvndtvg
tmmtcayeeptcevglivgtgsnacymeemknvemvegdqgqmcinmewgafgdngcldd
irthydrlvdeyslnagkqryekmisgmylgeivrnilidftkkgflfrgqisetlktrg
ifetkflsqiesdrlallqvrailqqlglnstcddsilvktvcgvvsrraaqlcgagmaa
vvdkirenrgldrlnvtvgvdgtlyklhphfsrimhqtvkelspkcnvsfllsedgsgkg
aalitavgvrlrteass

    Sequence, based on observed residues (ATOM records): (download) 
    >1hkbB (B:)
ddqvkkidkylyamrlsdetlidimtrfrkemknglsrdfnptatvkmlptfvrsipdgs
ekgdfialdlggssfrilrvqvnheknqnvhmesevydtpenivhgsgsqlfdhvaeclg
dfmekrkikdkklpvgftfsfpcqqskideailitwtkrfkasgvegadvvkllnkaikk
rgdydanivavvndtvgtmmtcgyddqhcevgliigtgtnacymeelrhidlvegdegrm
cintewgafgddgsledirtefdreidrgslnpgkqlfekmvsgmylgelvrlilvkmak
egllfegritpelltrgkfntsdvsaieknkeglhnakeiltrlgvepsdddcvsvqhvc
tivsfrsanlvaatlgailnrlrdnkgtprlrttvgvdgslykthpqysrrfhktlrrlv
pdsdvrfllsesgsgkgaamvtavayrlaeqhrqieetlahfhltkdmllevkkrmraem
elglrkqthnnavvkmlpsfvrrtpdgtengdflaldlggtnfrvllvkirsgkkrtvem
hnkiyaipieimqgtgeelfdhivscisdfldymgikgprmplgftfsfpcqqtsldagi
litwtkgfkatdcvghdvvtllrdaikrreefdldvvavvndtvgtmmtcayeeptcevg
livgtgsnacymeemknvemvegdqgqmcinmewgafgdngclddirthydrlvdeysln
agkqryekmisgmylgeivrnilidftkkgflfrgqisetlktrgifetkflsqiesdrl
allqvrailqqlglnstcddsilvktvcgvvsrraaqlcgagmaavvdkirenrgldrln
vtvgvdgtlyklhphfsrimhqtvkelspkcnvsfllsedgsgkgaalitavgvrlrte