PDB entry 1hdc

View 1hdc on RCSB PDB site
Description: mechanism of inhibition of 3alpha,20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor
Class: oxidoreductase
Keywords: oxidoreductase
Deposited on 1994-10-21, released 1995-02-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-29, with a file datestamp of 2017-11-24.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-alpha, 20 beta-hydroxysteroid dehydrogenase
    Species: Streptomyces exfoliatus [TaxId:1905]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19992 (0-253)
      • conflict (107)
    Domains in SCOPe 2.08: d1hdca_
  • Chain 'B':
    Compound: 3-alpha, 20 beta-hydroxysteroid dehydrogenase
    Species: Streptomyces exfoliatus [TaxId:1905]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19992 (0-253)
      • conflict (107)
    Domains in SCOPe 2.08: d1hdcb_
  • Chain 'C':
    Compound: 3-alpha, 20 beta-hydroxysteroid dehydrogenase
    Species: Streptomyces exfoliatus [TaxId:1905]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19992 (0-253)
      • conflict (107)
    Domains in SCOPe 2.08: d1hdcc_
  • Chain 'D':
    Compound: 3-alpha, 20 beta-hydroxysteroid dehydrogenase
    Species: Streptomyces exfoliatus [TaxId:1905]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19992 (0-253)
      • conflict (107)
    Domains in SCOPe 2.08: d1hdcd_
  • Heterogens: CBO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hdcA (A:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgnepgeiagavvkllsdtssyvtgaelavdg
gwttgptvkyvmgq

    Sequence, based on observed residues (ATOM records): (download) 
    >1hdcA (A:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgepgeiagavvkllsdtssyvtgaelavdgg
wttgptvkyvmgq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hdcB (B:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgnepgeiagavvkllsdtssyvtgaelavdg
gwttgptvkyvmgq

    Sequence, based on observed residues (ATOM records): (download) 
    >1hdcB (B:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgepgeiagavvkllsdtssyvtgaelavdgg
wttgptvkyvmgq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1hdcC (C:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgnepgeiagavvkllsdtssyvtgaelavdg
gwttgptvkyvmgq

    Sequence, based on observed residues (ATOM records): (download) 
    >1hdcC (C:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgepgeiagavvkllsdtssyvtgaelavdgg
wttgptvkyvmgq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1hdcD (D:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgnepgeiagavvkllsdtssyvtgaelavdg
gwttgptvkyvmgq

    Sequence, based on observed residues (ATOM records): (download) 
    >1hdcD (D:)
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgepgeiagavvkllsdtssyvtgaelavdgg
wttgptvkyvmgq