PDB entry 1hbt

View 1hbt on RCSB PDB site
Description: Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: serine protease, hydrolase-hydrolase inhibitor complex
Deposited on 1995-04-06, released 1995-07-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.181
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: alpha-thrombin (large subunit)
    Species: Homo sapiens [TaxId:9606]
    Gene: F2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1hbt.1
  • Chain 'I':
    Compound: P596 Inhibitor peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1HBT (0-End)
  • Chain 'L':
    Compound: alpha-thrombin (small subunit)
    Species: Homo sapiens [TaxId:9606]
    Gene: DKFZp470K2111, F2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1hbt.1
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1hbtH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hbtH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketgqpsvlqvvnlpiverpvckdstriritdnmfc
agykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlk
kwiqkvidqf

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1hbtL (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1hbtL (L:)
adcglrplfekksledkterellesyi