PDB entry 1hap

View 1hap on RCSB PDB site
Description: complex of human alpha-thrombin with a 15mer oligonucleotide ggttggtgtggttgg (based on x-ray model of DNA)
Class: hydrolase/hydrolase inhibitor/DNA
Keywords: coagulation/inhibitor/DNA, quadruple helix
Deposited on 1995-10-03, released 1996-04-03
The last revision prior to the SCOP 1.75 freeze date was dated 1996-04-03, with a file datestamp of 2007-07-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.161
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'D':
    Compound: DNA (5'-d(*gp*gp*tp*tp*gp*gp*tp*gp*tp*gp*gp*tp*tp*gp*g)-3')
  • Chain 'H':
    Compound: protein (alpha-thrombin - residues 16 - 247 (e.c.3.4.21.5))
    Species: HOMO SAPIENS
    Domains in SCOP 1.75: d1hap.1
  • Chain 'L':
    Compound: protein (alpha-thrombin - residues 1h - 15 (e.c.3.4.21.5))
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1hap.1
  • Chain 'P':
    Compound: d-phe-pro-arg-chloromethylketone (ppack)
  • Heterogens: CH2, HOH

PDB Chain Sequences:

  • Chain 'D':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1hapH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >1hapH (H:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwgqpsvlqvvnlpiverpvckdstriritdnmf
cagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrl
kkwiqkvidqfge

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1hapL (L:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >1hapL (L:)
adcglrplfekksledkterellesyi

  • Chain 'P':
    No sequence available.