PDB entry 1h4r

View 1h4r on RCSB PDB site
Description: crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein.
Class: structural protein
Keywords: ferm, neurofibromatosis, nf2, structural protein, cytoskeleton, anti-oncogene
Deposited on 2001-05-14, released 2002-01-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.193
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: merlin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1H4R
    • Uniprot P35240 (Start-313)
    Domains in SCOPe 2.05: d1h4ra1, d1h4ra2, d1h4ra3
  • Chain 'B':
    Compound: merlin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1H4R
    • Uniprot P35240 (Start-313)
    Domains in SCOPe 2.05: d1h4rb1, d1h4rb2, d1h4rb3
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1h4rA (A:)
gmagaiasrmsfsslkrkqpktftvrivtmdaemefncemkwkgkdlfdlvcrtlglret
wffglqytikdtvawlkmdkkvldhdvskeepvtfhflakfypenaeeelvqeitqhlff
lqvkkqildekiycppeasvllasyavqakygdydpsvhkrgflaqeellpkrvinlyqm
tpemweeritawyaehrgrardeaemeylkiaqdlemygvnyfairnkkgtelllgvdal
glhiydpenrltpkisfpwneirnisysdkeftikpldkkidvfkfnssklrvnklilql
cignhdlfmrrrka

    Sequence, based on observed residues (ATOM records): (download) 
    >1h4rA (A:)
ktftvrivtmdaemefncemkwkgkdlfdlvcrtlglretwffglqytikdtvawlkmdk
kvldhdvskeepvtfhflakfypenaeeelvqeitqhlfflqvkkqildekiycppeasv
llasyavqakygdydpsvhkrgflaqeellpkrvinlyqmtpemweeritawyaehrgra
rdeaemeylkiaqdlemygvnyfairnkkgtelllgvdalglhiydpenrltpkisfpwn
eirnisysdkeftikpldkkidvfkfnssklrvnklilqlcignhdlfmrrrka

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1h4rB (B:)
gmagaiasrmsfsslkrkqpktftvrivtmdaemefncemkwkgkdlfdlvcrtlglret
wffglqytikdtvawlkmdkkvldhdvskeepvtfhflakfypenaeeelvqeitqhlff
lqvkkqildekiycppeasvllasyavqakygdydpsvhkrgflaqeellpkrvinlyqm
tpemweeritawyaehrgrardeaemeylkiaqdlemygvnyfairnkkgtelllgvdal
glhiydpenrltpkisfpwneirnisysdkeftikpldkkidvfkfnssklrvnklilql
cignhdlfmrrrka

    Sequence, based on observed residues (ATOM records): (download) 
    >1h4rB (B:)
ktftvrivtmdaemefncemkwkgkdlfdlvcrtlglretwffglqytikdtvawlkmdk
kvldhdvskeepvtfhflakfypenaeeelvqeitqhlfflqvkkqildekiycppeasv
llasyavqakygdydpsvhkrgflaqeellpkrvinlyqmtpemweeritawyaehrgra
rdeaemeylkiaqdlemygvnyfairnkkgtelllgvdalglhiydpenrltpkisfpwn
eirnisysdkeftikpldkkidvfkfnssklrvnklilqlcignhdlfmrrrka