PDB entry 1h39

View 1h39 on RCSB PDB site
Description: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
Class: isomerase
Keywords: isomerase, cholesterol biosynthesis, inhibitor, monotopic membrane protein
Deposited on 2002-08-24, released 2003-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-06-13, with a file datestamp of 2018-06-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h39a1, d1h39a2
  • Chain 'B':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h39b1, d1h39b2
  • Chain 'C':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h39c1, d1h39c2
  • Heterogens: C8E, R03, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1h39A (A:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1h39A (A:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1h39B (B:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1h39B (B:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1h39C (C:)
maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
fpgdfylgytmyrhvfptlalgrykqaierr

    Sequence, based on observed residues (ATOM records): (download) 
    >1h39C (C:)
ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
tmyrhvfptlalgrykqaie