PDB entry 1h36

View 1h36 on RCSB PDB site
Description: Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme
Class: isomerase
Keywords: isomerase, cholesterol biosynthesis, inhibitor, monotopic membrane protein
Deposited on 2002-08-24, released 2003-08-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.221
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1h36a1, d1h36a2
  • Chain 'B':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1h36b1, d1h36b2
  • Chain 'C':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1h36c1, d1h36c2
  • Heterogens: C8E, R88, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1h36A (A:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h36A (A:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1h36B (B:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h36B (B:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1h36C (C:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h36C (C:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie