PDB entry 1h35

View 1h35 on RCSB PDB site
Description: Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme
Class: isomerase
Keywords: isomerase, cholesterol biosynthesis, inhibitor, monotopic membrane protein
Deposited on 2002-08-24, released 2003-08-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-06-13, with a file datestamp of 2018-06-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h35a1, d1h35a2
  • Chain 'B':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h35b1, d1h35b2
  • Chain 'C':
    Compound: squalene--hopene cyclase
    Species: Alicyclobacillus acidocaldarius [TaxId:405212]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h35c1, d1h35c2
  • Heterogens: C8E, R01, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1h35A (A:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h35A (A:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1h35B (B:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h35B (B:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1h35C (C:)
    maeqlveapayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdr
    mekirryllheqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsq
    ggiessrvftrmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsiv
    msrqpvfplperarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraa
    eiraldwllerqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyg
    gwmfqasispvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkp
    ggfafqfdnvyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgay
    dvdntsdlpnhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqk
    pdgswfgrwgvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsy
    edpayagkgastpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtg
    fpgdfylgytmyrhvfptlalgrykqaierr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h35C (C:)
    ayartldraveyllscqkdegywwgpllsnvtmeaeyvllchildrvdrdrmekirryll
    heqredgtwalypggppdldttieayvalkyigmsrdeepmqkalrfiqsqggiessrvf
    trmwlalvgeypwekvpmvppeimflgkrmplniyefgswaratvvalsivmsrqpvfpl
    perarvpelyetdvpprrrgakggggwifdaldralhgyqklsvhpfrraaeiraldwll
    erqagdgswggiqppwfyalialkildmtqhpafikgweglelygveldyggwmfqasis
    pvwdtglavlalraaglpadhdrlvkagewlldrqitvpgdwavkrpnlkpggfafqfdn
    vyypdvddtavvvwalntlrlpderrrrdamtkgfrwivgmqssnggwgaydvdntsdlp
    nhipfcdfgevtdppsedvtahvlecfgsfgyddawkvirraveylkreqkpdgswfgrw
    gvnylygtgavvsalkavgidtrepyiqkaldwveqhqnpdggwgedcrsyedpayagkg
    astpsqtawalmaliaggraeseaarrgvqylvetqrpdggwdepyytgtgfpgdfylgy
    tmyrhvfptlalgrykqaie