PDB entry 1h2y

View 1h2y on RCSB PDB site
Description: prolyl oligopeptidase from porcine brain, y473f mutant with covalently bound inhibitor z-pro-prolinal
Class: hydrolase
Keywords: hydrolase, prolyl oligopeptidase, amnesia, alpha/ beta-hydrolase, beta-propeller, serine protease
Deposited on 2002-08-20, released 2002-11-11
The last revision prior to the SCOP 1.75 freeze date was dated 2002-11-11, with a file datestamp of 2007-07-20.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: 0.172
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: prolyl endopeptidase
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23687 (0-709)
      • engineered mutation (472)
    Domains in SCOP 1.75: d1h2ya1, d1h2ya2
  • Heterogens: ZPR, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1h2yA (A:)
mlsfqypdvyrdetaiqdyhghkvcdpyawledpdseqtkafveaqnkitvpfleqcpir
glykermtelydypkyschfkkgkryfyfyntglqnqrvlyvqdslegearvfldpnils
ddgtvalrgyafsedgeyfayglsasgsdwvtikfmkvdgakelpdvlervkfscmawth
dgkgmfynaypqqdgksdgtetstnlhqklyyhvlgtdqsedilcaefpdepkwmggael
sddgryvllsiregcdpvnrlwycdlqqesngitgilkwvklidnfegeydyvtnegtvf
tfktnrhspnyrlinidftdpeeskwkvlvpehekdvlewvacvrsnflvlcylhdvknt
lqlhdlatgallkifplevgsvvgysgqkkdteifyqftsflspgiiyhcdltkeelepr
vfrevtvkgidasdyqtvqifypskdgtkipmfivhkkgikldgshpaflygfggfnisi
tpnysvsrlifvrhmggvlavanirgggeygetwhkggilankqncfddfqcaaeylike
gytspkrltinggsnggllvatcanqrpdlfgcviaqvgvmdmlkfhkytighawttdyg
csdskqhfewlikysplhnvklpeaddiqypsmllltadhddrvvplhslkfiatlqyiv
grsrkqnnpllihvdtkaghgagkptakvieevsdmfafiarclnidwip