PDB entry 1h2u

View 1h2u on RCSB PDB site
Description: Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Class: nuclear protein
Keywords: m7gcap, cap-binding-complex, rnp domain, mif4g domain, RNA maturation, RNA export, nuclear protein, RNA-binding
Deposited on 2002-08-16, released 2002-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 80 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q09161 (634-722)
      • engineered mutation (459)
    • PDB 1H2U (633-633)
    Domains in SCOPe 2.08: d1h2ua1, d1h2ua2, d1h2ua3
  • Chain 'B':
    Compound: 80 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q09161 (634-722)
      • engineered mutation (459)
    • PDB 1H2U (633-633)
    Domains in SCOPe 2.08: d1h2ub1, d1h2ub2, d1h2ub3
  • Chain 'X':
    Compound: 20 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h2ux_
  • Chain 'Y':
    Compound: 20 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h2uy_
  • Heterogens: GDP, 7MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1h2uA (A:)
    ktsdanetedhleslickvgeksacslesnleglagvleadlpnykskilrllctvarll
    pekltiyttlvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchv
    iaapsmvamfenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifant
    esylkrrqkthvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsi
    lcealqhnlppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlh
    ciikshwkerktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttlliel
    cklqpgslpqvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsq
    dpespkpkfvrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghs
    valclavafkskatndeifsilkdvpnpnqdddddegfsfnplkievfvqtllhlaaksf
    shsfsalakfhevfktlaesdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaav
    anwifsselsrdftrlfvweilhstirkmnkhvgaqseqknlflvifqrfimiltehlvr
    cetdgtsvltpwykncierlqqiflqhhqiiqqymvtlenllftaeldphilavfqqfca
    lqa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h2uA (A:)
    etedhleslickvgeksacslesnleglagvleadlpnykskilrllctvarllpeklti
    yttlvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchviaapsm
    vamfenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifantesylkr
    rqkthvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsilcealq
    hnlppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlhciiksh
    wkerktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttllielcklqpg
    slpqvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsqdpespk
    pkfvrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghsvalcla
    vafkskatndeifsilkdvpnpfnplkievfvqtllhlaaksfshsfsalakfhevfktl
    aesdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaavanwifsselsrdftrlf
    vweilhstirkmnkhvgaqseqknlflvifqrfimiltehlvrcetdgtsvltpwyknci
    erlqqiflqhhqiiqqymvtlenllftaeldphilavfqqfcalqa
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1h2uB (B:)
    ktsdanetedhleslickvgeksacslesnleglagvleadlpnykskilrllctvarll
    pekltiyttlvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchv
    iaapsmvamfenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifant
    esylkrrqkthvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsi
    lcealqhnlppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlh
    ciikshwkerktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttlliel
    cklqpgslpqvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsq
    dpespkpkfvrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghs
    valclavafkskatndeifsilkdvpnpnqdddddegfsfnplkievfvqtllhlaaksf
    shsfsalakfhevfktlaesdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaav
    anwifsselsrdftrlfvweilhstirkmnkhvgaqseqknlflvifqrfimiltehlvr
    cetdgtsvltpwykncierlqqiflqhhqiiqqymvtlenllftaeldphilavfqqfca
    lqa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h2uB (B:)
    tedhleslickvgeksacslesnleglagvleadlpnykskilrllctvarllpekltiy
    ttlvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchviaapsmv
    amfenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifantesylkrr
    qkthvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsilcealqh
    nlppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlhciikshw
    kerktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttllielcklqpgs
    lpqvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsqdpespkp
    kfvrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghsvalclav
    afkskatndeifsilkdvpnpsfnplkievfvqtllhlaaksfshsfsalakfhevfktl
    aesdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaavanwifsselsrdftrlf
    vweilhstirkmnkhvgaqseqknlflvifqrfimiltehlvrcetdgtsvltpwyknci
    erlqqiflqhhqiiqqymvtlenllftaeldphilavfqqfcalqa
    

  • Chain 'X':
    Sequence, based on SEQRES records: (download)
    >1h2uX (X:)
    msggllkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelf
    sksgdikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfk
    egrqygrgrsggqvrdeyrqdydagrggygklaqnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h2uX (X:)
    gllkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelfsks
    gdikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfkegr
    qygrgrsggqvrdeyrqdydagrggygkl
    

  • Chain 'Y':
    Sequence, based on SEQRES records: (download)
    >1h2uY (Y:)
    msggllkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelf
    sksgdikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfk
    egrqygrgrsggqvrdeyrqdydagrggygklaqnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h2uY (Y:)
    llkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelfsksg
    dikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfkegrq
    ygrgrsggqvrdeyrqdydagrggygk