PDB entry 1gzh

View 1gzh on RCSB PDB site
Description: Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor
Class: gene regulation
Keywords: gene regulation, anti-oncogene, DNA-binding, transcription regulation, bcrt domain, apoptosis, disease mutation, activator, DNA- repair
Deposited on 2002-05-22, released 2002-06-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.238
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-197)
      • conflict (133)
    Domains in SCOPe 2.08: d1gzha_
  • Chain 'B':
    Compound: tumor suppressor p53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1gzhb1, d1gzhb2
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1gzhc_
  • Chain 'D':
    Compound: tumor suppressor p53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1gzhd1, d1gzhd2
  • Heterogens: ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1gzhA (A:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsecttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenlrkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1gzhA (A:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercappqhlirveglrveylddrntfrhsvvvpye
ppecttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrvcacpgrdrrte
eenlrkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1gzhB (B:)
lnktlflgyaflltmattsdklasrsklpdgptgsseeeeefleippfnkqytesqlrag
agyiledfneaqcntayqclliadqhcrtrkyflclasgipcvshvwvhdschanqlqny
rnyllpagysleeqrildwqprenpfqnlkvllvsdqqqnflelwseilmtggaasvkqh
hssahnkdialgvfdvvvtdpscpasvlkcaealqlpvvsqewviqclivgerigfkqhp
kykhdyvsh

    Sequence, based on observed residues (ATOM records): (download) 
    >1gzhB (B:)
lnktlflgyaflltmattsdklasrsppfnkqytesqlragagyiledfntayqclliad
qhcrtrkyflclasgipcvshvwvhdschanqlqnyrnyllpagysleeqrildwqpren
pfqnlkvllvsdqqqnflelwseilmtggaasvkqhhssahnkdialgvfdvvvtdpscp
asvlkcaealqlpvvsqewviqclivgerigfkqhpkykhdyvsh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1gzhC (C:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenlrkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1gzhC (C:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevrv
cacpgrdrrteeenlr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1gzhD (D:)
lnktlflgyaflltmattsdklasrsklpdgptgsseeeeefleippfnkqytesqlrag
agyiledfneaqcntayqclliadqhcrtrkyflclasgipcvshvwvhdschanqlqny
rnyllpagysleeqrildwqprenpfqnlkvllvsdqqqnflelwseilmtggaasvkqh
hssahnkdialgvfdvvvtdpscpasvlkcaealqlpvvsqewviqclivgerigfkqhp
kykhdyvsh

    Sequence, based on observed residues (ATOM records): (download) 
    >1gzhD (D:)
nktlflgyaflltmatfnkqytesqlragagyiledfnentayqclliadqhcrtrkyfl
clasgipcvshvwvhdschanqlqnyrnyllpagysleeqrildwqprenpfqnlkvllv
sdqqqnflelwseilmtggaasvkqhhssahnkdialgvfdvvvtdpscpasvlkcaeal
qlpvvsqewviqclivgerigfkqhpkykhdyv