PDB entry 1gxf

View 1gxf on RCSB PDB site
Description: crystal structure of trypanosoma cruzi trypanothione reductase in complex with the inhibitor quinacrine mustard
Class: oxidoreductase
Keywords: oxidoreductase, trypanothione reductase, fad dependent, disulphide oxidoreductase, quinacrine mustard, inhibitor, redox-active center, flavoprotein, fad, nadp
Deposited on 2002-04-04, released 2004-05-06
The last revision prior to the SCOP 1.73 freeze date was dated 2004-07-08, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.19
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: trypanothione reductase (oxidized form); synonym; n(1),n(8)-bis(glutathionyl)spermidine reductase
    Species: Trypanosoma cruzi
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28593
      • variant (94)
      • variant (111)
      • variant (155)
      • variant (352)
      • variant (401-402)
      • variant (440)
    Domains in SCOP 1.73: d1gxfa1, d1gxfa2, d1gxfa3
  • Chain 'B':
    Compound: trypanothione reductase (oxidized form); synonym; n(1),n(8)-bis(glutathionyl)spermidine reductase
    Species: Trypanosoma cruzi
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28593
      • variant (94)
      • variant (111)
      • variant (155)
      • variant (352)
      • variant (401-402)
      • variant (440)
    Domains in SCOP 1.73: d1gxfb1, d1gxfb2, d1gxfb3
  • Heterogens: FAD, MAE, QUM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1gxfA (A:)
mmskifdlvvigagsggleaawnaatlykkrvavidvqmvhgppffsalggtcvnvgcvp
kklmvtgaqymehlresagfgwefdrttlraewknliavkdeavlninksydemfrdteg
lefflgwgslesknvvnvresadpasavkerletehillasgswphmpnipgiehcissn
eafylpepprrvltvgggfisvefagifnaykpkdgqvtlcyrgemilrgfdhtlreelt
kqltangiqiltkenpakvelnadgsksvtfesgkkmdfdlvmmaigrsprtkdlqlqna
gvmiknggvqvdeysrtnvsniyaigdvtnrvmltpvaineaaalvdtvfgttprktdht
rvasavfsippigtcglieevaskryevvavylssftplmhkvsgskyktfvakiitnhs
dgtvlgvhllgdnapeiiqgigiclklnakisdfyntigvhptsaeelcsmrtpsyyyvk
gekmekpseasl

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxfA (A:)
kifdlvvigagsggleaawnaatlykkrvavidvqmvhgppffsalggtcvnvgcvpkkl
mvtgaqymehlresagfgwefdrttlraewknliavkdeavlninksydemfrdteglef
flgwgslesknvvnvresadpasavkerletehillasgswphmpnipgiehcissneaf
ylpepprrvltvgggfisvefagifnaykpkdgqvtlcyrgemilrgfdhtlreeltkql
tangiqiltkenpakvelnadgsksvtfesgkkmdfdlvmmaigrsprtkdlqlqnagvm
iknggvqvdeysrtnvsniyaigdvtnrvmltpvaineaaalvdtvfgttprktdhtrva
savfsippigtcglieevaskryevvavylssftplmhkvsgskyktfvakiitnhsdgt
vlgvhllgdnapeiiqgigiclklnakisdfyntigvhptsaeelcsmrtpsyyyvkgek
mekps

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1gxfB (B:)
mmskifdlvvigagsggleaawnaatlykkrvavidvqmvhgppffsalggtcvnvgcvp
kklmvtgaqymehlresagfgwefdrttlraewknliavkdeavlninksydemfrdteg
lefflgwgslesknvvnvresadpasavkerletehillasgswphmpnipgiehcissn
eafylpepprrvltvgggfisvefagifnaykpkdgqvtlcyrgemilrgfdhtlreelt
kqltangiqiltkenpakvelnadgsksvtfesgkkmdfdlvmmaigrsprtkdlqlqna
gvmiknggvqvdeysrtnvsniyaigdvtnrvmltpvaineaaalvdtvfgttprktdht
rvasavfsippigtcglieevaskryevvavylssftplmhkvsgskyktfvakiitnhs
dgtvlgvhllgdnapeiiqgigiclklnakisdfyntigvhptsaeelcsmrtpsyyyvk
gekmekpseasl

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxfB (B:)
ifdlvvigagsggleaawnaatlykkrvavidvqmvhgppffsalggtcvnvgcvpkklm
vtgaqymehlresagfgwefdrttlraewknliavkdeavlninksydemfrdtegleff
lgwgslesknvvnvresadpasavkerletehillasgswphmpnipgiehcissneafy
lpepprrvltvgggfisvefagifnaykpkdgqvtlcyrgemilrgfdhtlreeltkqlt
angiqiltkenpakvelnadgsksvtfesgkkmdfdlvmmaigrsprtkdlqlqnagvmi
knggvqvdeysrtnvsniyaigdvtnrvmltpvaineaaalvdtvfgttprktdhtrvas
avfsippigtcglieevaskryevvavylssftplmhkvsgskyktfvakiitnhsdgtv
lgvhllgdnapeiiqgigiclklnakisdfyntigvhptsaeelcsmrtpsyyyvkgekm
ekps