PDB entry 1gxd

View 1gxd on RCSB PDB site
Description: proMMP-2/TIMP-2 complex
Class: hydrolase
Keywords: hydrolase, metalloprotease, zymogen, collagen degradation, extracellular matrix, gelatinase a, matrix metalloproteinase 2, proteinase inhibitor
Deposited on 2002-04-02, released 2002-07-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 72 kda type IV collagenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08253 (0-630)
      • engineered mutation (374)
    Domains in SCOPe 2.08: d1gxda1, d1gxda2, d1gxda3, d1gxda4, d1gxda5, d1gxda6
  • Chain 'B':
    Compound: 72 kda type IV collagenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08253 (Start-630)
      • engineered mutation (374)
    Domains in SCOPe 2.08: d1gxdb1, d1gxdb2, d1gxdb3, d1gxdb4, d1gxdb5, d1gxdb6
  • Chain 'C':
    Compound: metalloproteinase inhibitor 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1gxdc_
  • Chain 'D':
    Compound: metalloproteinase inhibitor 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1gxdd_
  • Heterogens: SO4, ZN, CA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1gxdA (A:)
apspiikfpgdvapktdkelavqylntfygcpkescnlfvlkdtlkkmqkffglpqtgdl
dqntietmrkprcgnpdvanynffprkpkwdknqityriigytpdldpetvddafarafq
vwsdvtplrfsrihdgeadiminfgrwehgdgypfdgkdgllahafapgtgvggdshfdd
delwtlgegqvvrvkygnadgeyckfpflfngkeynsctdtgrsdgflwcsttynfekdg
kygfcphealftmggnaegqpckfpfrfqgtsydscttegrtdgyrwcgttedydrdkky
gfcpetamstvggnsegapcvfpftflgnkyesctsagrsdgkmwcattanydddrkwgf
cpdqgyslflvaahafghamglehsqdpgalmapiytytknfrlsqddikgiqelygasp
didlgtgptptlgpvtpeickqdivfdgiaqirgeifffkdrfiwrtvtprdkpmgpllv
atfwpelpekidavyeapqeekavffagneywiysastlergypkpltslglppdvqrvd
aafnwsknkktyifagdkfwrynevkkkmdpgfpkliadawnaipdnldavvdlqggghs
yffkgayylklenqslksvkfgsiksdwlgc

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxdA (A:)
apspiikfpgdvapktdkelavqylntfygcpkescnlfvlkdtlkkmqkffglpqtgdl
dqntietmrkprcgnpdvanynffprkpkwdknqityriigytpdldpetvddafarafq
vwsdvtplrfsrihdgeadiminfgrwehgdgypfdgkdgllahafapgtgvggdshfdd
delwtlgegqvvrvkygnadgeyckfpflfngkeynsctdtgrsdgflwcsttynfekdg
kygfcphealftmggnaegqpckfpfrfqgtsydscttegrtdgyrwcgttedydrdkky
gfcpetamstvggnsegapcvfpftflgnkyesctsagrsdgkmwcattanydddrkwgf
cpdqgyslflvaahafghamglehsqdpgalmapiytytknfrlsqddikgiqelygasp
dtptlgpvtpeickqdivfdgiaqirgeifffkdrfiwrtvtprdkpmgpllvatfwpel
pekidavyeapqeekavffagneywiysastlergypkpltslglppdvqrvdaafnwsk
nkktyifagdkfwrynevkkkmdpgfpkliadawnaipdnldavvdlqggghsyffkgay
ylklenqslksvkfgsiksdwlgc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1gxdB (B:)
apspiikfpgdvapktdkelavqylntfygcpkescnlfvlkdtlkkmqkffglpqtgdl
dqntietmrkprcgnpdvanynffprkpkwdknqityriigytpdldpetvddafarafq
vwsdvtplrfsrihdgeadiminfgrwehgdgypfdgkdgllahafapgtgvggdshfdd
delwtlgegqvvrvkygnadgeyckfpflfngkeynsctdtgrsdgflwcsttynfekdg
kygfcphealftmggnaegqpckfpfrfqgtsydscttegrtdgyrwcgttedydrdkky
gfcpetamstvggnsegapcvfpftflgnkyesctsagrsdgkmwcattanydddrkwgf
cpdqgyslflvaahafghamglehsqdpgalmapiytytknfrlsqddikgiqelygasp
didlgtgptptlgpvtpeickqdivfdgiaqirgeifffkdrfiwrtvtprdkpmgpllv
atfwpelpekidavyeapqeekavffagneywiysastlergypkpltslglppdvqrvd
aafnwsknkktyifagdkfwrynevkkkmdpgfpkliadawnaipdnldavvdlqggghs
yffkgayylklenqslksvkfgsiksdwlgc

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxdB (B:)
pspiikfpgdvapktdkelavqylntfygcpkescnlfvlkdtlkkmqkffglpqtgdld
qntietmrkprcgnpdvanynffprkpkwdknqityriigytpdldpetvddafarafqv
wsdvtplrfsrihdgeadiminfgrwehgdgypfdgkdgllahafapgtgvggdshfddd
elwtlgegqvvrvkygnadgeyckfpflfngkeynsctdtgrsdgflwcsttynfekdgk
ygfcphealftmggnaegqpckfpfrfqgtsydscttegrtdgyrwcgttedydrdkkyg
fcpetamstvggnsegapcvfpftflgnkyesctsagrsdgkmwcattanydddrkwgfc
pdqgyslflvaahafghamglehsqdpgalmapiytytknfrlsqddikgiqelygaspd
tptlgpvtpeickqdivfdgiaqirgeifffkdrfiwrtvtprdkpmgpllvatfwpelp
ekidavyeapqeekavffagneywiysastlergypkpltslglppdvqrvdaafnwskn
kktyifagdkfwrynevkkkmdpgfpkliadawnaipdnldavvdlqggghsyffkgayy
lklenqslksvkfgsiksdwlgc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1gxdC (C:)
cscspvhpqqafcnadvvirakavsekevdsgndiygnpikriqyeikqikmfkgpekdi
efiytapssavcgvsldvggkkeyliagkaegdgkmhitlcdfivpwdtlsttqkkslnh
ryqmgceckitrcpmipcyisspdeclwmdwvtekninghqakffacikrsdgscawyrg
aappkqefldiedp

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxdC (C:)
cscspvhpqqafcnadvvirakavsekevdsgndiygnpikriqyeikqikmfkgpekdi
efiytapssavcgvsldvggkkeyliagkaegdgkmhitlcdfivpwdtlsttqkkslnh
ryqmgceckitrcpmipcyisspdeclwmdwvtekninghqakffacikrsdgscawyrg
aappkqefldie

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1gxdD (D:)
cscspvhpqqafcnadvvirakavsekevdsgndiygnpikriqyeikqikmfkgpekdi
efiytapssavcgvsldvggkkeyliagkaegdgkmhitlcdfivpwdtlsttqkkslnh
ryqmgceckitrcpmipcyisspdeclwmdwvtekninghqakffacikrsdgscawyrg
aappkqefldiedp

    Sequence, based on observed residues (ATOM records): (download) 
    >1gxdD (D:)
cscspvhpqqafcnadvvirakavsekevdsgndiygnpikriqyeikqikmfkgpekdi
efiytapssavcgvsldvggkkeyliagkaegdgkmhitlcdfivpwdtlsttqkkslnh
ryqmgceckitrcpmipcyisspdeclwmdwvtekninghqakffacikrsdgscawyrg
aappkqefldie