SCOPe 2.02: Structural Classification of Proteins

PDB entry 1gte

View 1gte on RCSB PDB site
Description: dihydropyrimidine dehydrogenase (dpd) from pig, binary complex with 5-iodouracil
Class: oxidoreductase
Keywords: electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
Deposited on 2002-01-15, released 2002-04-11
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.181
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: dihydropyrimidine dehydrogenase
Species: Sus scrofa [TaxId:9823]
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.02: d1gtea1, d1gtea2, d1gtea3, d1gtea4, d1gtea5
Chain 'B':
Compound: dihydropyrimidine dehydrogenase
Species: Sus scrofa [TaxId:9823]
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.02: d1gteb1, d1gteb2, d1gteb3, d1gteb4, d1gteb5
Chain 'C':
Compound: dihydropyrimidine dehydrogenase
Species: Sus scrofa [TaxId:9823]
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.02: d1gtec1, d1gtec2, d1gtec3, d1gtec4, d1gtec5
Chain 'D':
Compound: dihydropyrimidine dehydrogenase
Species: Sus scrofa [TaxId:9823]
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOPe 2.02: d1gted1, d1gted2, d1gted3, d1gted4, d1gted5
Heterogens: SF4, FMN, FAD, IUR, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1gteA (A:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gteA (A:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraake
ggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralp
gfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieel
qgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnerkpf
ipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiq
fdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'B':
Sequence, based on SEQRES records: (download)

>1gteB (B:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gteB (B:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeg
gadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpg
fpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelq
gwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnerkpfi
pkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiqf
dpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglp

Chain 'C':
Sequence, based on SEQRES records: (download)

>1gteC (C:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gteC (C:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmlacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeg
gadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpg
fpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelq
gwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafppl
erkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsg
yqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'D':
Sequence, based on SEQRES records: (download)

>1gteD (D:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gteD (D:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
alerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcnd
sgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpl