SCOP 1.73: Structural Classification of Proteins

PDB entry 1gt8

View 1gt8 on RCSB PDB site
Description: dihydropyrimidine dehydrogenase (dpd) from pig, ternary complex with nadph and uracil-4-acetic acid
Class: oxidoreductase
Keywords: electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
Deposited on 2002-01-14, released 2002-04-11
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.214
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOP 1.73: d1gt8a1, d1gt8a2, d1gt8a3, d1gt8a4, d1gt8a5
Chain 'B':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOP 1.73: d1gt8b1, d1gt8b2, d1gt8b3, d1gt8b4, d1gt8b5
Chain 'C':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOP 1.73: d1gt8c1, d1gt8c2, d1gt8c3, d1gt8c4, d1gt8c5
Chain 'D':
Compound: dihydropyrimidine dehydrogenase
Species: SUS SCROFA
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
Domains in SCOP 1.73: d1gt8d1, d1gt8d2, d1gt8d3, d1gt8d4, d1gt8d5
Heterogens: SF4, FMN, FAD, NDP, UAA

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1gt8A (A:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gt8A (A:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgemglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiara
akeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiar
alpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksi
eelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaa
fpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtc
ndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla

Chain 'B':
Sequence, based on SEQRES records: (download)

>1gt8B (B:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gt8B (B:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraa
keggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiara
lpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksie
elqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqlerk
pfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqa
iqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla

Chain 'C':
Sequence, based on SEQRES records: (download)

>1gt8C (C:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gt8C (C:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscplacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeggad
gvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpgfpi
latggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelqgwd
gqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafpplerk
pfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqa
iqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla

Chain 'D':
Sequence, based on SEQRES records: (download)

>1gt8D (D:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records): (download)

>1gt8D (D:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlscphgmgmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraa
keggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiara
lpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksie
elqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnple
rkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgy
qaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla