PDB entry 1gj8

View 1gj8 on RCSB PDB site
Description: engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets
Class: BLOOD CLOTTING, hydrolase
Keywords: selectivity at S1, H2O displacement, uPA, tPA, Ser190/Ala190 protease, structure-based drug design, BLOOD CLOTTING, hydrolase
Deposited on 2001-04-27, released 2002-04-27
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: 0.188
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: urokinase-type plasminogen activator
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1gj8.1
  • Chain 'B':
    Compound: urokinase-type plasminogen activator
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00749 (0-End)
      • conflict (143)
    Domains in SCOPe 2.01: d1gj8.1
  • Heterogens: CIT, 133, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1gj8A (A:)
kpssppeelkfqcgqktlrprfk

    Sequence, based on observed residues (ATOM records): (download) 
    >1gj8A (A:)
ppeelkfqcgqkt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1gj8B (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irshtkeenglal

    Sequence, based on observed residues (ATOM records): (download) 
    >1gj8B (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irsht