PDB entry 1gi9
View 1gi9 on RCSB PDB site
Description: a novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site
Class: BLOOD CLOTTING, hydrolase
Keywords: three-centered, very short hydrogen bond, oxyanion hole water,
shift of pKa of His57, structure-based drug design, specificity, urokinase,
trypsin, thrombin, Zn+2-mediated inhibition
Deposited on
2001-01-22, released
2002-01-22
The last revision prior to the SCOP 1.75 freeze date was dated
2003-04-01, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.192
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: urokinase-type plasminogen activator
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1gi9.1 - Chain 'B':
Compound: urokinase-type plasminogen activator
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1gi9.1 - Heterogens: 123, CIT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1gi9A (A:)
kpssppeelkfqcgqktlrprfk
Sequence, based on observed residues (ATOM records): (download)
>1gi9A (A:)
lkfqcgqkt
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1gi9B (B:)
iiggefttienqpwfaaiyrrhrggsvtyvcggslmspcwvisathcfidypkkedyivy
lgrsrlnsntqgemkfevenlilhkdysadtlahhndiallkirskegrcaqpsrtiqti
clpsmyndpqfgtsceitgfgkeastdylypeqlkmtvvklishrecqqphyygsevttk
mlcaadpqwktdscqgdsggplvcslqgrmtltgivswgrgcalkdkpgvytrvshflpw
irsht