PDB entry 1gc1

View 1gc1 on RCSB PDB site
Description: hiv-1 gp120 core complexed with cd4 and a neutralizing human antibody
Class: Viral protein/receptor/Immune system
Keywords: COMPLEX (HIV ENVELOPE PROTEIN-CD4-FAB), HIV-1 EXTERIOR ENVELOPE GP120, T-CELL SURFACE GLYCOPROTEIN CD4, ANTIGEN-BINDING FRAGMENT OF HUMAN IMMUNOGLOBULIN 17B, GLYCOSYLATED PROTEIN, Viral protein-receptor-Immune system COMPLEX
Deposited on 1998-06-15, released 1998-07-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.21
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: cd4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1gc1c1, d1gc1c2
  • Chain 'G':
    Compound: envelope protein gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04578 (238-320)
      • conflict (15)
      • conflict (174)
      • conflict (298)
    • PDB 1GC1 (155-157)
    Domains in SCOPe 2.06: d1gc1g_
  • Chain 'H':
    Compound: antibody 17b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1GC1 (0-228)
    Domains in SCOPe 2.06: d1gc1h1, d1gc1h2
  • Chain 'L':
    Compound: antibody 17b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1GC1 (0-212)
    Domains in SCOPe 2.06: d1gc1l1, d1gc1l2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1gc1C (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >1gc1C (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    k
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1gc1G (G:)
    garsevvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvit
    qacpkvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqllln
    gslaeeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklre
    qfgnnktiifkqssggdpeivthsfncggeffycnstqlfnstwfnstwstkgsnntegs
    dtitlpcrikqiinmwqkvgkamyappisgqircssnitgllltrdggnsnneseifrpg
    ggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >1gc1G (G:)
    tenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvitqacpkvsfepi
    pihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqlllngslaeeevvir
    svnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklreqfgnnktiifk
    qssggdpeivthsfncggeffycnstqlfnstwfgsdtitlpcrikqiinmwqkvgkamy
    appisgqircssnitgllltrdggnsnneseifrpgggdmrdnwrselykykvvkie
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1gc1H (H:)
    qvqllesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
    aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
    gtlvtvtsastkgpsvfplapsskstsggtaalgclvkdyfpqpvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1gc1L (L:)
    eleltqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
    rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
    ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
    ltlskadyekhkvyacevthqglsspvtksfnr