PDB entry 1ga5

View 1ga5 on RCSB PDB site
Description: crystal structure of the orphan nuclear receptor rev-erb(alpha) DNA-binding domain bound to its cognate response element
Class: transcription/DNA
Keywords: orphan receptor, nuclear receptor, DNA-binding, reverb, rev-erb, transcription-DNA complex
Deposited on 2000-11-29, released 2001-11-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: orphan nuclear receptor nr1d1
  Species: Homo sapiens [TaxId:9606]
  Gene: NR1D1 OR THRAL OR EAR1 OR HREV
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20393
    • cloning artifact (24)
  Domains in SCOPe 2.08: d1ga5a_
• Chain 'B':
  Compound: orphan nuclear receptor nr1d1
  Species: Homo sapiens [TaxId:9606]
  Gene: NR1D1 OR THRAL OR EAR1 OR HREV
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20393
    • cloning artifact (24)
  Domains in SCOPe 2.08: d1ga5b_
• Chain 'C':
  Compound: 5'-d(*cp*ap*ap*cp*tp*ap*gp*gp*tp*cp*ap*cp*tp*ap*gp*gp*tp*cp*ap*g)-3'
  Species: synthetic, synthetic
  
• Chain 'D':
  Compound: 5'-d(*cp*tp*gp*ap*cp*cp*tp*ap*gp*tp*gp*ap*cp*cp*tp*ap*gp*tp*(5it)p*g)-3'
  Species: synthetic, synthetic
  
• Chain 'E':
  Compound: orphan nuclear receptor nr1d1
  Species: Homo sapiens [TaxId:9606]
  Gene: NR1D1 OR THRAL OR EAR1 OR HREV
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20393
    • cloning artifact (24)
  Domains in SCOPe 2.08: d1ga5e_
• Chain 'F':
  Compound: orphan nuclear receptor nr1d1
  Species: Homo sapiens [TaxId:9606]
  Gene: NR1D1 OR THRAL OR EAR1 OR HREV
  Database cross-references and differences (RAF-indexed):
  • Uniprot P20393
    • cloning artifact (24)
  Domains in SCOPe 2.08: d1ga5f_
• Chain 'G':
  Compound: 5'-d(*cp*ap*ap*cp*tp*ap*gp*gp*tp*cp*ap*cp*tp*ap*gp*gp*tp*cp*ap*g)-3'
  Species: synthetic, synthetic
  
• Chain 'H':
  Compound: 5'-d(*cp*tp*gp*ap*cp*cp*tp*ap*gp*tp*gp*ap*cp*cp*tp*ap*gp*tp*(5it)p*g)-3'
  Species: synthetic, synthetic
  
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >1ga5A (A:)
  tklngmvllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinr
  nrcqqcrfkkclsvgmsrdavrfgripkrekqrm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >1ga5A (A:)
  vllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinrnrcqqc
  rfkkclsvgmsrdavrfgripk
  

  
  
• Chain 'B':
  Sequence, based on SEQRES records: (download)
  

  >1ga5B (B:)
  tklngmvllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinr
  nrcqqcrfkkclsvgmsrdavrfgripkrekqrm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >1ga5B (B:)
  vllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinrnrcqqc
  rfkkclsvgmsrdavrfgr
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  Sequence, based on SEQRES records: (download)
  

  >1ga5E (E:)
  tklngmvllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinr
  nrcqqcrfkkclsvgmsrdavrfgripkrekqrm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >1ga5E (E:)
  vllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinrnrcqqc
  rfkkclsvgmsrdavrfgrip
  

  
  
• Chain 'F':
  Sequence, based on SEQRES records: (download)
  

  >1ga5F (F:)
  tklngmvllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinr
  nrcqqcrfkkclsvgmsrdavrfgripkrekqrm
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >1ga5F (F:)
  vllckvcgdvasgfhygvlacegckgffrrsiqqniqykrclknencsivrinrnrcqqc
  rfkkclsvgmsrdavrfg
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.