PDB entry 1g9m

View 1g9m on RCSB PDB site
Description: hiv-1 hxbc2 gp120 envelope glycoprotein complexed with cd4 and induced neutralizing antibody 17b
Class: Viral protein/Immune system
Keywords: complex (hiv envelope protein/cd4/fab), hiv-1 exterior envelope gp120 from laboratory-adapted isolate, hxbc2, surface T-cell glycoprotein cd4, antigen-binding fragment of human immunoglobulin 17b
Deposited on 2000-11-24, released 2000-12-27
The last revision prior to the SCOP 1.73 freeze date was dated 2000-12-27, with a file datestamp of 2007-06-14.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.268
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1g9mc1, d1g9mc2
  • Chain 'G':
    Compound: envelope glycoprotein gp120
    Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04578 (4-48)
      • see remark 999 (49-51)
      • see remark 999 (155-157)
    • Uniprot P04578 (52-154)
    • Uniprot P04578 (158-320)
    Domains in SCOP 1.73: d1g9mg_
  • Chain 'H':
    Compound: antibody 17b, heavy chain
    Species: HOMO SAPIENS
    Domains in SCOP 1.73: d1g9mh1, d1g9mh2
  • Chain 'L':
    Compound: antibody 17b, light chain
    Species: HOMO SAPIENS
    Domains in SCOP 1.73: d1g9ml1, d1g9ml2
  • Heterogens: NDG, NAG, IPA, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1g9mC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >1g9mC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    k
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1g9mG (G:)
    garsevvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvit
    qacpkvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqllln
    gslaeeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklre
    qfgnnktiifkqssggdpeivthsfncggeffycnstqlfnstwfnstwstegsnntegs
    dtitlpcrikqiinmwqkvgkamyappisgqircssnitgllltrdggnsnneseifrpg
    ggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >1g9mG (G:)
    evvlvnvtenfnmwkndmveqmhediislwdqslkpcvkltplcvgagscntsvitqacp
    kvsfepipihycapagfailkcnnktfngtgpctnvstvqcthgirpvvstqlllngsla
    eeevvirsvnftdnaktiivqlntsveinctgaghcnisrakwnntlkqiasklreqfgn
    nktiifkqssggdpeivthsfncggeffycnstqlfnstwfngsdtitlpcrikqiinmw
    qkvgkamyappisgqircssnitgllltrdggnsnneseifrpgggdmrdnwrselykyk
    vvkie
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1g9mH (H:)
    qvqllesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
    aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeyrnngflkhwgq
    gtlvtvtsastkgpsvfplapsskstsggtaalgclvkdyfpqpvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1g9mL (L:)
    eleltqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
    rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
    ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqkskdstyslsst
    ltlskadyekhkvyacevthqglsspvtksfnrg