PDB entry 1g3n

View 1g3n on RCSB PDB site
Description: structure of a p18(ink4c)-cdk6-k-cyclin ternary complex
Class: cell cycle, signaling protein
Keywords: Cyclin-dependent kinase, INK4 inhibitor, Viral cyclin, cell cycle, signaling protein
Deposited on 2000-10-24, released 2001-01-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYCLIN-DEPENDENT KINASE 6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1g3na_
  • Chain 'B':
    Compound: cyclin-dependent kinase 6 inhibitor
    Species: Homo sapiens [TaxId:9606]
    Gene: P18(INK4C)
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1g3nb_
  • Chain 'C':
    Compound: v-cyclin
    Species: Human herpesvirus 8 [TaxId:37296]
    Gene: K-CYCLIN (VIRAL CYCLIND HOMOLOG)
    Database cross-references and differences (RAF-indexed):
    • Uniprot O40946
      • conflict (162)
      • conflict (187)
    Domains in SCOPe 2.08: d1g3nc1, d1g3nc2
  • Chain 'E':
    Compound: cyclin-dependent kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYCLIN-DEPENDENT KINASE 6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1g3ne_
  • Chain 'F':
    Compound: cyclin-dependent kinase 6 inhibitor
    Species: Homo sapiens [TaxId:9606]
    Gene: P18(INK4C)
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1g3nf_
  • Chain 'G':
    Compound: v-cyclin
    Species: Human herpesvirus 8 [TaxId:37296]
    Gene: K-CYCLIN (VIRAL CYCLIND HOMOLOG)
    Database cross-references and differences (RAF-indexed):
    • Uniprot O40946
      • conflict (162)
      • conflict (187)
    Domains in SCOPe 2.08: d1g3ng1, d1g3ng2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1g3nA (A:)
mekdglcradqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstir
evavlrhletfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvpte
tikdmmfqllrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvv
vtlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpge
edwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyf
qdlerckenldshlppsqntselnta

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nA (A:)
adqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhl
etfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfq
llrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrap
evllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdva
lprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1g3nB (B:)
maepwgnelasaaargdleqltsllqnnvnvnaqngfgrtalqvmklgnpeiarrlllrg
anpdlkdrtgfavihdaaragfldtlqtllefqadvniednegnlplhlaakeghlrvve
flvkhtasnvghrnhkgdtacdlarlygrnevvslmqangaggatnlq

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nB (B:)
gnelasaaargdleqltsllqnnvnvnaqngfgrtalqvmklgnpeiarrlllrganpdl
kdrtgfavihdaaragfldtlqtllefqadvniednegnlplhlaakeghlrvveflvkh
tasnvghrnhkgdtacdlarlygrnevvslmqang

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1g3nC (C:)
matannppsglldptlcedrifynileieprfltsdsvfgtfqqsltshmrkllgtwmfs
vcqeynlepnvvalalnlldrlllikqvskehfqktgsacllvasklrsltpistsslcy
aaadsfsrqelidqekelleklawrteavlatdvtsflllklvggsqhldfwhhevntli
tkalvdpltgslpasiisaagcallvpanvipqdthsggvvpqlasilgcdvsvlqaave
qiltsvsdfdlrildsy

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nC (C:)
lcedrifynileieprfltsdsvfgtfqqsltshmrkllgtwmfsvcqeynlepnvvala
lnlldrlllikqvskehfqktgsacllvasklrsltpistsslcyaaadsfsrqelidqe
kelleklawrteavlatdvtsflllklvggsqhldfwhhevntlitkalvdpltgslpas
iisaagcallvpanvipqgvvpqlasilgcdvsvlqaaveqiltsvsdfdlri

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1g3nE (E:)
mekdglcradqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstir
evavlrhletfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvpte
tikdmmfqllrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvv
vtlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpge
edwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyf
qdlerckenldshlppsqntselnta

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nE (E:)
adqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhl
etfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfq
llrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrap
evllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdva
lprqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1g3nF (F:)
maepwgnelasaaargdleqltsllqnnvnvnaqngfgrtalqvmklgnpeiarrlllrg
anpdlkdrtgfavihdaaragfldtlqtllefqadvniednegnlplhlaakeghlrvve
flvkhtasnvghrnhkgdtacdlarlygrnevvslmqangaggatnlq

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nF (F:)
gnelasaaargdleqltsllqnnvnvnaqngfgrtalqvmklgnpeiarrlllrganpdl
kdrtgfavihdaaragfldtlqtllefqadvniednegnlplhlaakeghlrvveflvkh
tasnvghrnhkgdtacdlarlygrnevvslmqang

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1g3nG (G:)
matannppsglldptlcedrifynileieprfltsdsvfgtfqqsltshmrkllgtwmfs
vcqeynlepnvvalalnlldrlllikqvskehfqktgsacllvasklrsltpistsslcy
aaadsfsrqelidqekelleklawrteavlatdvtsflllklvggsqhldfwhhevntli
tkalvdpltgslpasiisaagcallvpanvipqdthsggvvpqlasilgcdvsvlqaave
qiltsvsdfdlrildsy

    Sequence, based on observed residues (ATOM records): (download) 
    >1g3nG (G:)
lcedrifynileieprfltsdsvfgtfqqsltshmrkllgtwmfsvcqeynlepnvvala
lnlldrlllikqvskehfqktgsacllvasklrsltpistsslcyaaadsfsrqelidqe
kelleklawrteavlatdvtsflllklvggsqhldfwhhevntlitkalvdpltgslpas
iisaagcallvpanvipqgvvpqlasilgcdvsvlqaaveqiltsvsdfdlri