PDB entry 1fvd
View 1fvd on RCSB PDB site
Description: x-ray structures of the antigen-binding domains from three variants of humanized anti-p185-her2 antibody 4d5 and comparison with molecular modeling
Class: immunoglobulin
Keywords: immunoglobulin
Deposited on
1992-10-20, released
1993-10-31
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-29, with a file datestamp of
2017-11-24.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.19
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: igg1-kappa 4d5 fab (light chain)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- EMBL CAA65061 (3-213)
- conflict (13)
- conflict (27-33)
- conflict (49)
- conflict (52)
- conflict (54)
- conflict (65)
- conflict (90-92)
- conflict (95)
- conflict (102-103)
Domains in SCOPe 2.08: d1fvda1, d1fvda2 - Chain 'B':
Compound: igg1-kappa 4d5 fab (heavy chain)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- EMBL CAA75030 (1-222)
- conflict (27-33)
- conflict (42)
- conflict (45)
- conflict (48)
- conflict (51)
- conflict (53-56)
- conflict (58)
- conflict (62)
- conflict (71)
- conflict (73-74)
- conflict (84)
- conflict (96)
- insertion (98-99)
- conflict (101-102)
- conflict (104-105)
- conflict (108)
Domains in SCOPe 2.08: d1fvdb1, d1fvdb2 - Chain 'C':
Compound: igg1-kappa 4d5 fab (light chain)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- EMBL CAA65061 (3-213)
- conflict (13)
- conflict (27-33)
- conflict (49)
- conflict (52)
- conflict (54)
- conflict (65)
- conflict (90-92)
- conflict (95)
- conflict (102-103)
Domains in SCOPe 2.08: d1fvdc1, d1fvdc2 - Chain 'D':
Compound: igg1-kappa 4d5 fab (heavy chain)
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- EMBL CAA75030 (1-222)
- conflict (27-33)
- conflict (42)
- conflict (45)
- conflict (48)
- conflict (51)
- conflict (53-56)
- conflict (58)
- conflict (62)
- conflict (71)
- conflict (73-74)
- conflict (84)
- conflict (96)
- insertion (98-99)
- conflict (101-102)
- conflict (104-105)
- conflict (108)
Domains in SCOPe 2.08: d1fvdd1, d1fvdd2 - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1fvdA (A:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflesgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1fvdB (B:)
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntlylqmnslraedtavyycsrwggdgfyamdvwgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1fvdC (C:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflesgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1fvdD (D:)
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntlylqmnslraedtavyycsrwggdgfyamdvwgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc