PDB entry 1fvc

View 1fvc on RCSB PDB site
Description: x-ray structures of the antigen-binding domains from three variants of humanized anti-p185-her2 antibody 4d5 and comparison with molecular modeling
Class: immunoglobulin
Keywords: immunoglobulin
Deposited on 1992-10-20, released 1993-10-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-08-25, with a file datestamp of 2009-08-21.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.183
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg1-kappa 4d5 fv (light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAA59089 (0-108)
      • conflict (27-33)
      • conflict (49)
      • conflict (52)
      • conflict (54)
      • conflict (65)
      • conflict (90)
      • conflict (92)
    Domains in SCOPe 2.06: d1fvca_
  • Chain 'B':
    Compound: igg1-kappa 4d5 fv (heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1FVC (0-119)
    Domains in SCOPe 2.06: d1fvcb_
  • Chain 'C':
    Compound: igg1-kappa 4d5 fv (light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAA59089 (0-End)
      • conflict (27-33)
      • conflict (49)
      • conflict (52)
      • conflict (54)
      • conflict (65)
      • conflict (90)
      • conflict (92)
    Domains in SCOPe 2.06: d1fvcc_
  • Chain 'D':
    Compound: igg1-kappa 4d5 fv (heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1FVC (0-119)
    Domains in SCOPe 2.06: d1fvcd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1fvcA (A:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrt

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1fvcB (B:)
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1fvcC (C:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikrt

    Sequence, based on observed residues (ATOM records): (download) 
    >1fvcC (C:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysasflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkveikr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1fvcD (D:)
evqlvesggglvqpggslrlscaasgfnikdtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdywgqgtlvtvss